DC Field | Value | Language |
---|---|---|
dc.contributor.author | Youn, Jong-Chan | ko |
dc.contributor.author | Jung, Min Kyung | ko |
dc.contributor.author | Yu, Hee Tae | ko |
dc.contributor.author | Kwon, Jisoo | ko |
dc.contributor.author | Kwak, Jeongeun | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Kim, In-Cheol | ko |
dc.contributor.author | Park, Myung-Soo | ko |
dc.contributor.author | Lee, Sun Ki | ko |
dc.contributor.author | Choi, Suk-Won | ko |
dc.contributor.author | Han, Seongwoo | ko |
dc.contributor.author | Ryu, Kyu-Hyung | ko |
dc.contributor.author | Kang, Seok-Min | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2019-10-02T10:21:30Z | - |
dc.date.available | 2019-10-02T10:21:30Z | - |
dc.date.created | 2019-10-01 | - |
dc.date.created | 2019-10-01 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.9 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/267749 | - |
dc.description.abstract | Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 +/- 16 years) and 38 healthy control subjects (21 males, mean age 62 +/- 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57(+) T cells in the CD4(+) T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4(+)CD57(+) T cell population exhibited a higher frequency of IFN-gamma-and TNF-alpha-producing cells compared to the CD4(+)CD57(-)T cell population. Furthermore, the frequency of CD4(+)CD57(+) T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4(+)CD57(+) senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Increased frequency of CD4(+)CD57(+) senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance | - |
dc.type | Article | - |
dc.identifier.wosid | 000484657300011 | - |
dc.identifier.scopusid | 2-s2.0-85071983694 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/s41598-019-49332-5 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Youn, Jong-Chan | - |
dc.contributor.nonIdAuthor | Kim, In-Cheol | - |
dc.contributor.nonIdAuthor | Park, Myung-Soo | - |
dc.contributor.nonIdAuthor | Lee, Sun Ki | - |
dc.contributor.nonIdAuthor | Choi, Suk-Won | - |
dc.contributor.nonIdAuthor | Han, Seongwoo | - |
dc.contributor.nonIdAuthor | Ryu, Kyu-Hyung | - |
dc.contributor.nonIdAuthor | Kang, Seok-Min | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | IMMUNE-MECHANISMS | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | THERAPY | - |
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