Enhanced formation of axonal collateral Bbranching of hippocampal neurons on h-PDMS nanopillar arrayh-PDMS 나노기둥 기판에서의 해마 신경세포의 축색돌기 가지 형성 촉진

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Axonal branches, one of the features of neuronal development, extending from one axon make it possible for individual neurons to establish synapses with multiple targets. This complex structural connection in a nervous system allows one neuron to transmit a wide range of signals to multiple neurons, which is essential for performing various functions of the nervous system such as learning, memory, sensation, and response. The Microtubules and the actin filament induced the formation of the axonal branches. In this work, we used an h-PDMS nanopillar array which was fabricated from AAO mold as a culture platform. We found that the h-PDMS nanopillar array not only promoted the growth of the axon, but also significantly increased the number of axonal branches of primary hippocampal neurons. Also, we found that h-PDMS nanopillar array induced condensation of F-actin on the axon shaft using various inhibitors. A study on the effect of topographical environment on axonal branch formation not only can contribute to expanding knowledge of the cell-biological mechanism of regulation of branch formation, but also contribute to the formation of the high-ordered neural system.
Advisors
Choi, Insung S.researcher최인성researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2017
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 화학과, 2017.8,[iii, 34 p. :]

Keywords

Hippocampal neurons▼aaxonal collateral branches▼amicrotubule▼aF-actin▼ananopillar array; 해마 신경세포▼a축색돌기 가지▼aF-actin▼aMicrotubule▼a나도기둥 기판

URI
http://hdl.handle.net/10203/267346
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=867043&flag=dissertation
Appears in Collection
CH-Theses_Master(석사논문)
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