Studies on site-selective catalytic reactions for efficient synthesis of biologically privileged scaffolds위치선택적 촉매 반응을 통한 생리활성 골격체의 효율적인 합성에 대한 연구

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Developing efficient strategies for the synthesis of biologically active compounds is indisputably the most important topic in organic chemistry. This thesis describes experimental and computational studies on the site-selective catalytic reactions to enable efficient synthesis of functionalized quinolones, phosphorus-containing amino acid derivatives, and valuable cyclic compounds. Divergent C–C bond formation reactions of quinolones have been achieved by site-selective C–H activation using directing groups. Regiodivergent ring-opening cross-coupling of vinyl aziridines with phosphorus nucleophiles has been developed for the facile and efficient synthesis of enantioenriched phosphorus-containing amino acid derivatives. Moreover, synthetic methodologies involving C–H activation have been developed for construction of privileged ring systems including benzazepines, carbazoles, and lactones. Mechanistic investigations using density functional theory were also conducted to elucidate the reaction mechanism.
Advisors
Hong, Sungwooresearcher홍승우researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 2019.2,[ii, 88 p. :]

Keywords

catalysis▼asite-selectivity▼aquinolone▼aaziridine▼aamino acid▼acyclic compound▼adensity functional theory; 촉매 반응▼a위치선택성▼a퀴놀론▼a아지리딘▼a아미노산▼a고리화합물▼a밀도범함수

URI
http://hdl.handle.net/10203/265524
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842530&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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