Development of protein assemblies as functional scaffolds for biosensing and bioimaging = 바이오센싱 및 바이오이미징을 위한 단백질 조립체 개발에 관한 연구

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Natural protein assemblies have been extensively studied and exploited as biomolecular scaffolds with rich functionalities and well-defined structures. Recent advances in designing artificial protein nanostructures through self-assembling features have enabled the understanding of the basic mechanisms in protein assemblies and the construction of diverse functional biomaterials for not only biosensing and clinical diagnosis but also molecular imaging. This paper outlines the design and fabrication of novel protein nanostructures and their applications in biosensing and live cell imaging. Chapter 1 provides general research background. Chapter 2 covers the sophisticated design of the rigidity and space controllable protein assembly based on a split green fluorescence protein (GFP) system. Chapter 3 describes manufacturing a highly sensitive and specific biosensor for the detection of influenza virus by harnessing multivalency in the GFP assembly. Chapter 4 presents the development of a quantum dot (QD) based cell imaging probe for practical labeling by engineering SpyCatcher and the avidin protein.
Advisors
Jung, Yongwonresearcher정용원researcher
Description
한국과학기술원 :화학과,
Publisher
한국과학기술원
Issue Date
2019
Identifier
325007
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 화학과, 2019.2,[viii, 150 p. :]

Keywords

Protein assembly▼amultivalency▼abiosensor▼aavidin protein▼alive cell imaging; 단백질 조립체▼a다중결합▼a바이오센서▼a아비딘▼a세포 이미징

URI
http://hdl.handle.net/10203/265509
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=842465&flag=dissertation
Appears in Collection
CH-Theses_Ph.D.(박사논문)
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