Synaptic organizer: Slitrks and type IIa receptor protein tyrosine phosphatases

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Slit-like and Trk-like (Slitrk) family members are leucine-rich repeat (LRR)-containing neuronal transmembrane proteins. Slitrks have been highlighted as key synapse organizers at neuronal synapses through interactions with specific members of the presynaptic type Ha receptor protein tyrosine phosphatase (RPTP) family. Recent structural studies on type IIa RPTP/Slitrkl complexes have unveiled molecular insights into their binding selectivity and have established the role of higher-order receptor clustering in their synaptogenic activity. Here, we will discuss key structural aspects of Slitrk interactions with type IIa RPTP family members, the biological roles of Slitrks in neurons, and our current knowledge of SLITRK mutations in human diseases.
Publisher
CURRENT BIOLOGY LTD
Issue Date
2019-02
Language
English
Article Type
Review
Citation

CURRENT OPINION IN STRUCTURAL BIOLOGY, v.54, pp.95 - 103

ISSN
0959-440X
DOI
10.1016/j.sbi.2019.01.010
URI
http://hdl.handle.net/10203/263762
Appears in Collection
MSE-Journal Papers(저널논문)
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