DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Yeni | ko |
dc.contributor.author | Hwang, Woo Chang | ko |
dc.contributor.author | Kim, JiYeon | ko |
dc.contributor.author | Lee, Choong Hwan | ko |
dc.contributor.author | Kim, Yong-Jae | ko |
dc.contributor.author | Lee, Doheon | ko |
dc.contributor.author | Kwon, Oran | ko |
dc.date.accessioned | 2019-07-23T06:21:12Z | - |
dc.date.available | 2019-07-23T06:21:12Z | - |
dc.date.created | 2019-07-23 | - |
dc.date.created | 2019-07-23 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.9 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/263745 | - |
dc.description.abstract | With the increased risk of cardiovascular disease, the use of botanicals for vascular endothelial dysfunction has intensified. Here, we explored the synergistic mechanisms of Sang huang-Danshen (SD) phytochemicals on the homeostatic protection against high-fat-induced vascular dysfunction in healthy subjects, using a network biology approach, based on a randomised crossover clinical trial. Seventeen differential markers identified in blood samples taken at 0, 3 and 6 h post-treatment, together with 12SD phytochemicals, were mapped onto the network platform, termed the context-oriented directed associations. The resulting vascular sub-networks illustrated associations between 10 phytochemicals with 32 targets implicated in 143 metabolic/signalling pathways. The three key events included adhesion molecule production (ellagic acid, fumaric acid and cryptotanshinone; VCAM-1, ICAM-1 and PLA2G2A; fatty acid metabolism), platelet activation (ellagic acid, protocatechuic acid and tanshinone IIA; VEGFA, APAF1 and ATF3; mTOR, p53, Rap1 and VEGF signalling pathways) and endothelial inflammation (all phytochemicals, except cryptotanshinone; 29 targets, including TP53 and CASP3; MAPK and PI3K-Akt signalling pathways, among others). Our collective findings demonstrate a potential of SD to protect unintended risks of vascular dysfunction in healthy subjects, providing a deeper understanding of the complicated synergistic mechanisms of signature phytochemicals in SD. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Synergistic mechanisms of Sanghuang-Danshen phytochemicals on postprandial vascular dysfunction in healthy subjects: A network biology approach based on a clinical trial | - |
dc.type | Article | - |
dc.identifier.wosid | 000474230900026 | - |
dc.identifier.scopusid | 2-s2.0-85068361433 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/s41598-019-46289-3 | - |
dc.contributor.localauthor | Lee, Doheon | - |
dc.contributor.nonIdAuthor | Lim, Yeni | - |
dc.contributor.nonIdAuthor | Kim, JiYeon | - |
dc.contributor.nonIdAuthor | Lee, Choong Hwan | - |
dc.contributor.nonIdAuthor | Kim, Yong-Jae | - |
dc.contributor.nonIdAuthor | Kwon, Oran | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | ENDOTHELIAL DYSFUNCTION | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PLATELET | - |
dc.subject.keywordPlus | FAT | - |
dc.subject.keywordPlus | PROFILES | - |
dc.subject.keywordPlus | RISK | - |
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