Transient effect of mossy fiber stimulation on spatial firing of CA3 neurons

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 59
  • Download : 0
Strong hippocampal mossy fiber synapses are thought to function as detonators, imposing "teaching" signals onto CA3 neurons during new memory formation. For an empirical test of this long-standing view, we examined effects of optogenetically stimulating mossy fibers on spatial firing of CA3 neurons in freely-moving mice. We found that spatially restricted mossy fiber stimulation drives novel place-specific firing in some CA3 pyramidal neurons. Such neurons comprise only a minority, however, and many more CA3 neurons showed inhibited spatial firing during mossy fiber stimulation. Also, changes in spatial firing induced by mossy fiber stimulation, both activated and inhibited, reverted immediately upon stimulation termination, leaving CA3 place fields unaltered. Our results do not support the traditional view that mossy fibers impose teaching signals onto CA3 network, and show robustness of established CA3 spatial representations.
Publisher
WILEY
Issue Date
2019-07
Language
English
Article Type
Article
Citation

HIPPOCAMPUS, v.29, no.7, pp.639 - 651

ISSN
1050-9631
DOI
10.1002/hipo.23066
URI
http://hdl.handle.net/10203/263018
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0