Melamine-promoted formation of bright and stable DNA-silver nanoclusters and their antimicrobial properties

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dc.contributor.authorEun, Hyunminko
dc.contributor.authorKwon, Woo Youngko
dc.contributor.authorKalimuthu, Kalishwaralalko
dc.contributor.authorKim, Yonghwanko
dc.contributor.authorLee, Miranko
dc.contributor.authorAhn, Jung-Ohko
dc.contributor.authorLee, Hongweonko
dc.contributor.authorLee, Sang Hyunko
dc.contributor.authorKim, Hyung Jooko
dc.contributor.authorPark, Hyun Gyuko
dc.contributor.authorPark, Ki Sooko
dc.date.accessioned2019-05-15T13:25:44Z-
dc.date.available2019-05-15T13:25:44Z-
dc.date.created2019-05-13-
dc.date.created2019-05-13-
dc.date.created2019-05-13-
dc.date.issued2019-04-
dc.identifier.citationJOURNAL OF MATERIALS CHEMISTRY B, v.7, no.15, pp.2512 - 2517-
dc.identifier.issn2050-750X-
dc.identifier.urihttp://hdl.handle.net/10203/261867-
dc.description.abstractA new method has been developed for the preparation of brightly fluorescent and stable DNA-silver nanoclusters (DNA-AgNCs). The approach takes advantage of specific interactions occurring between melamine and thymine residues in a DNA template. These interactions cause the formation of a melamine-DNA-AgNC complex (Mel-DNA-AgNCs), in which a change in the environment of the DNA template causes binding of additional Ag+ and an enhancement in the fluorescence efficiency and stability. The effects of the nature of the template DNA, DNA:Ag+:NaBH4 ratio, pH and temperature were systematically assessed in order to maximize the melamine-promoted fluorescence enhancement. The results show that the Mel-DNA-AgNCs, generated under the optimal conditions, exhibit a ca. 3-fold larger fluorescence efficiency and long-term stability (70 d) in contrast to those of DNA-AgNCs in the absence of melamine. Importantly, the bright and stable Mel-DNA-AgNCs exhibit antimicrobial activities against Gram-positive and Gram-negative bacteria that are superior to those of DNA-AgNCs alone. To the best of our knowledge, this is the first report describing the synthesis of DNA-AgNCs that have improved fluorescence efficiencies and that function as effective antimicrobial agents.-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleMelamine-promoted formation of bright and stable DNA-silver nanoclusters and their antimicrobial properties-
dc.typeArticle-
dc.identifier.wosid000465281100010-
dc.identifier.scopusid2-s2.0-85064155383-
dc.type.rimsART-
dc.citation.volume7-
dc.citation.issue15-
dc.citation.beginningpage2512-
dc.citation.endingpage2517-
dc.citation.publicationnameJOURNAL OF MATERIALS CHEMISTRY B-
dc.identifier.doi10.1039/c8tb03166e-
dc.contributor.localauthorPark, Hyun Gyu-
dc.contributor.nonIdAuthorEun, Hyunmin-
dc.contributor.nonIdAuthorKwon, Woo Young-
dc.contributor.nonIdAuthorKalimuthu, Kalishwaralal-
dc.contributor.nonIdAuthorKim, Yonghwan-
dc.contributor.nonIdAuthorLee, Miran-
dc.contributor.nonIdAuthorAhn, Jung-Oh-
dc.contributor.nonIdAuthorLee, Hongweon-
dc.contributor.nonIdAuthorLee, Sang Hyun-
dc.contributor.nonIdAuthorKim, Hyung Joo-
dc.contributor.nonIdAuthorPark, Ki Soo-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusANTIBACTERIAL ACTIVITY-
dc.subject.keywordPlusFLUORESCENT-
dc.subject.keywordPlusION-
dc.subject.keywordPlusASSAY-
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