Extremely low frequency magnetic field induces oxidative stress in mouse cerebellum
We have investigated whether extremely low frequency magnetic field (ELF-MF) induces lipid peroxidation and reactive oxygen species in mouse cerebellum. After exposure to 60 Hz ELF-MF at 2.3 mT intensity for 3 hours, there was a significant increase in malondialdehyde level and hydroxyl radical. ELF-MF significantly induced concomitant increase in superoxide dismutase without alteration in glutathione peroxidase activity. While glutathione contents were not altered, ascorbic acid levels were significantly decreased by ELF-MF exposure. These results indicate that ELF-MF may induce oxidative stress in mouse cerebellum. However, the mechanism remains further to be characterized.
- Publisher
- GENERAL PHYSIOL AND BIOPHYSICS
- Issue Date
- 2011-12
- Language
- English
- Article Type
- Article
- Keywords
FREE-RADICAL PROCESSES; RAT-BRAIN; GLUTATHIONE-PEROXIDASE; OCCUPATIONAL-EXPOSURE; SUPEROXIDE-DISMUTASE; VITAMIN-C; ANTIOXIDANT; HIPPOCAMPUS; INVOLVEMENT; SCAVENGERS
- Citation
GENERAL PHYSIOLOGY AND BIOPHYSICS, v.30, no.4, pp.415 - 421
- ISSN
- 0231-5882
- Appears in Collection
- RIMS Journal Papers
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