Development of apoptosis-inducing polypeptide via simultaneous mitochondrial membrane disruption and Ca2+ delivery

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Mitochondria are the primary organelle of regulating apoptosis, and intracellular calcium ions are a key component of pro-apoptosis induction. Herein, we report an artificial apoptosis-inducing polypeptide that destabilizes the mitochondrial membrane and transports calcium ions into the cytosol, thereby synergistically creating severe oxidative conditions. The oxidative stress highly activates an apoptotic signaling cascade, and also inhibits cell migration and invasion in vitro and in vivo. The suggested strategy for simultaneous mitochondrial disruption and perturbed calcium homeostasis demonstrates the applicability of polypeptide-based therapeutics as potent apoptosis-inducers in cancer therapy.
Publisher
ELSEVIER SCI LTD
Issue Date
2019-03
Language
English
Article Type
Article
Citation

BIOMATERIALS, v.197, pp.51 - 59

ISSN
0142-9612
DOI
10.1016/j.biomaterials.2019.01.006
URI
http://hdl.handle.net/10203/251777
Appears in Collection
CBE-Journal Papers(저널논문)
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