Solar-Driven Biocatalytic C-Hydroxylation through Direct Transfer of Photoinduced Electrons

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dc.contributor.authorLe, Thien-Kimko
dc.contributor.authorPark, Jong Hyunko
dc.contributor.authorChoi, Da Somko
dc.contributor.authorLee, Ga-Youngko
dc.contributor.authorChoi, Woo Sungko
dc.contributor.authorJeong, Ki Junko
dc.contributor.authorPark, Chan Beumko
dc.contributor.authorYun, Chul-Hoko
dc.date.accessioned2019-03-19T01:26:45Z-
dc.date.available2019-03-19T01:26:45Z-
dc.date.created2018-12-06-
dc.date.created2018-12-06-
dc.date.issued2019-02-
dc.identifier.citationGREEN CHEMISTRY, v.21, no.3, pp.515 - 525-
dc.identifier.issn1463-9262-
dc.identifier.urihttp://hdl.handle.net/10203/251643-
dc.description.abstractDespite the immense potential of P450s, the dependence on the nicotinamide cofactor (NADPH) and NADPH-P450 reductase (CPR) limits their employment in the chemical industry. Here, we present a visible light-driven platform for biocatalytic C-hydroxylation reactions using natural flavin molecules, especially flavin mononucleotide, as a photosensitizer. By employing visible light as a source of energy instead of the nicotinamide cofactor, the bacterial CYP102A1 heme domain was successfully applied for photobiocatalytic C-hydroxylation of 4-nitrophenol and lauric acid – in the absence of NADPH and CPR. We present a proof of concept that the photoactivation of flavins is productively coupled with the direct transfer of photoinduced electrons to the P450 heme iron, achieving photobiocatalytic C-hydroxylation reactions.-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleSolar-Driven Biocatalytic C-Hydroxylation through Direct Transfer of Photoinduced Electrons-
dc.typeArticle-
dc.identifier.wosid000457794700032-
dc.identifier.scopusid2-s2.0-85061175236-
dc.type.rimsART-
dc.citation.volume21-
dc.citation.issue3-
dc.citation.beginningpage515-
dc.citation.endingpage525-
dc.citation.publicationnameGREEN CHEMISTRY-
dc.identifier.doi10.1039/C8GC02398K-
dc.contributor.localauthorJeong, Ki Jun-
dc.contributor.localauthorPark, Chan Beum-
dc.contributor.nonIdAuthorLe, Thien-Kim-
dc.contributor.nonIdAuthorLee, Ga-Young-
dc.contributor.nonIdAuthorYun, Chul-Ho-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusHUMAN METABOLITES-
dc.subject.keywordPlusP450 BM3-
dc.subject.keywordPlusCYTOCHROME-P450 SYSTEMS-
dc.subject.keywordPlusCARBENE TRANSFER-
dc.subject.keywordPlusENZYME-ACTIVITY-
dc.subject.keywordPlusGENERATION-
dc.subject.keywordPlusSUBSTRATE-
dc.subject.keywordPlusCYP102A1-
dc.subject.keywordPlusPROTOTYPE-
dc.subject.keywordPlusFLAVINS-
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CBE-Journal Papers(저널논문)MS-Journal Papers(저널논문)
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