HS-173 as a novel inducer of RIP3-dependent necroptosis in lung cancer

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 76
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorPark, Jung Heeko
dc.contributor.authorJung, Kyung Heeko
dc.contributor.authorKim, Soo Jungko
dc.contributor.authorYoon, Young-Chanko
dc.contributor.authorYan, Hong Huako
dc.contributor.authorFang, Zhenghuanko
dc.contributor.authorLee, Ji Eunko
dc.contributor.authorLim, Joo Hanko
dc.contributor.authorMah, Shinmeeko
dc.contributor.authorHong, Sungwooko
dc.contributor.authorKim, You-Sunko
dc.contributor.authorHong, Soon-Sunko
dc.date.accessioned2019-03-19T01:06:01Z-
dc.date.available2019-03-19T01:06:01Z-
dc.date.created2019-02-18-
dc.date.issued2019-01-
dc.identifier.citationCANCER LETTERS, v.444, pp.94 - 104-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://hdl.handle.net/10203/251515-
dc.description.abstractNecroptosis is a form of regulated necrotic cell death mediated by receptor-interacting kinase 3 (RIP3). Recently, necroptosis has gained attention as a novel alternative therapy to target cancer cells. In this study, we screened several chemotherapeutics used in preclinical and clinical studies, and identified a drug HS-173 that induces RIP3-mediated necroptosis. HS-173 decreased the cell survival in a dose-dependent manner in RIP3-expressing lung cancer cells, compared to the cells lacking RIP3. Also, the cell death induced by HS-173 was rescued by specific necroptosis inhibitors such as necrostatin-1 and dabrafenib. Additionally, HS-173 increased the phosphorylation of RIP3 and MLKL, which was decreased by necroptosis inhibitors, indicating that HS-173 activates RIP3/MLKL signaling in lung cancer cells. HS-173 increased the necroptotic events, as observed by the increased levels of HMGB1 and necroptotic morphological features. Furthermore, HS-173 inhibited the tumor growth by stimulation of necroptosis in mouse xenograft models. Our findings offer new insights into the role of HS-173 in inducing necroptosis by enhancing RIP3 expression and activating the RIP3/MLKL signaling pathway in lung cancer cells.-
dc.languageEnglish-
dc.publisherELSEVIER IRELAND LTD-
dc.titleHS-173 as a novel inducer of RIP3-dependent necroptosis in lung cancer-
dc.typeArticle-
dc.identifier.wosid000457505400009-
dc.identifier.scopusid2-s2.0-85059150046-
dc.type.rimsART-
dc.citation.volume444-
dc.citation.beginningpage94-
dc.citation.endingpage104-
dc.citation.publicationnameCANCER LETTERS-
dc.identifier.doi10.1016/j.canlet.2018.12.006-
dc.contributor.localauthorHong, Sungwoo-
dc.contributor.nonIdAuthorPark, Jung Hee-
dc.contributor.nonIdAuthorJung, Kyung Hee-
dc.contributor.nonIdAuthorKim, Soo Jung-
dc.contributor.nonIdAuthorYoon, Young-Chan-
dc.contributor.nonIdAuthorYan, Hong Hua-
dc.contributor.nonIdAuthorFang, Zhenghuan-
dc.contributor.nonIdAuthorLee, Ji Eun-
dc.contributor.nonIdAuthorLim, Joo Han-
dc.contributor.nonIdAuthorKim, You-Sun-
dc.contributor.nonIdAuthorHong, Soon-Sun-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorNecroptosis-
dc.subject.keywordAuthorRIP3-
dc.subject.keywordAuthorMLKL-
dc.subject.keywordAuthorLung cancer-
dc.subject.keywordAuthorHS-173-
dc.subject.keywordPlusMIXED LINEAGE KINASE-
dc.subject.keywordPlusPI3K INHIBITOR-
dc.subject.keywordPlusCELL-DEATH-
dc.subject.keywordPlusANTICANCER ACTIVITY-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusCHEMOTHERAPY-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusRIP3-
Appears in Collection
CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0