Genome-Scale Metabolic Reconstruction of Actinomycetes for Antibiotics Production

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Systems biology approaches are increasingly applied to explore the potential of actinomycetes for the discovery and optimal production of antibiotics. In particular, genome-scale metabolic models (GEMs) of various actinomycetes are reconstructed at a faster rate in recent years, which has opened avenues to study interaction between primary and secondary metabolism at systems level, and to predict gene manipulation targets for overproduction of important antibiotics. Here, the status of actinomycetes' GEMs and their applications for designing antibiotics-overproducing strains are presented. Despite advances in the practice of GEM reconstruction, actinomycetes' GEMs still remain incomplete in describing a full set of biosynthetic pathways of secondary metabolites. As to the GEM-based strategies, various simulation methods are deployed to better describe secondary metabolism by introducing changes in constraints and/or objective function as well as by using omics data. Gene manipulation targeting algorithms developed for metabolic engineering of model organisms have also been actively applied to actinomycetes for the antibiotics production. Further consideration of computational resources dedicated to secondary metabolites in addition with automated GEM reconstruction tools will further upgrade GEMs of actinomycetes for antibiotics discovery and development.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2019-01
Language
English
Article Type
Review
Citation

BIOTECHNOLOGY JOURNAL, v.14, no.1

ISSN
1860-6768
DOI
10.1002/biot.201800377
URI
http://hdl.handle.net/10203/250406
Appears in Collection
CBE-Journal Papers(저널논문)
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