Generation of a highly efficient and tissue-specific tryptophan hydroxylase 1 knockout mouse model

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dc.contributor.authorKim, Hyeongseokko
dc.contributor.authorKim, Yeong Giko
dc.contributor.authorChoi, Wonsukko
dc.contributor.authorMoon, Joon Hoko
dc.contributor.authorHwang, Inseonko
dc.contributor.authorKim, Kyu Hoko
dc.contributor.authorYadav, Vijay K.ko
dc.contributor.authorKarsenty, Gerardko
dc.contributor.authorJeong, Ji-Seonko
dc.contributor.authorKim, Hailko
dc.date.accessioned2019-01-22T08:57:52Z-
dc.date.available2019-01-22T08:57:52Z-
dc.date.created2018-12-31-
dc.date.created2018-12-31-
dc.date.issued2018-12-
dc.identifier.citationSCIENTIFIC REPORTS, v.8-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10203/249161-
dc.description.abstractRecent studies on tissue-autonomous serotonin (5-hydroxytryptamine [5-HT]) function have identified new roles for 5-HT in peripheral organs. Most of these studies were performed by crossing mice carrying the Tph1(tm1Kry) allele with tissue specific Cre mice. In the present study, we found that 5-HT production was not completely abolished in Tph1(tm1Kry) KO mice. The residual 5-HT production in Tph1(tm1Kry) KO mice is attributed to the expression of a truncated form of TPH1 containing the catalytic domain. Hence, in an effort to obtain mice with a Tph1 null phenotype, we generated mice harboring a new Tph1 floxed allele, Tph1(tm1c), targeting exons 5 and 6 which encode the catalytic domain of TPH1. By crossing the new Tph1 floxed mice with villin-Cre or insulin-Cre mice, we observed near-complete ablation of 5-HT production in the intestine and beta cells. In conclusion, this improved Tph1 floxed mouse model will serve as useful and accurate tool for analyzing peripheral 5-HT system.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleGeneration of a highly efficient and tissue-specific tryptophan hydroxylase 1 knockout mouse model-
dc.typeArticle-
dc.identifier.wosid000452204400011-
dc.identifier.scopusid2-s2.0-85057730137-
dc.type.rimsART-
dc.citation.volume8-
dc.citation.publicationnameSCIENTIFIC REPORTS-
dc.identifier.doi10.1038/s41598-018-36097-6-
dc.contributor.localauthorKim, Hail-
dc.contributor.nonIdAuthorYadav, Vijay K.-
dc.contributor.nonIdAuthorKarsenty, Gerard-
dc.contributor.nonIdAuthorJeong, Ji-Seon-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusPERIPHERAL SEROTONIN-
dc.subject.keywordPlusINSULIN-SECRETION-
dc.subject.keywordPlusMASS-
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MSE-Journal Papers(저널논문)
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