Curcumin as a Novel Nanocarrier System for Doxorubicin Delivery to MDR Cancer Cells: In Vitro and in Vivo Evaluation

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dc.contributor.authorRejinold, Sanoj N.ko
dc.contributor.authorYoo, Jisangko
dc.contributor.authorJon, Sangyongko
dc.contributor.authorKim, Yeu-Chunko
dc.date.accessioned2018-12-20T08:06:24Z-
dc.date.available2018-12-20T08:06:24Z-
dc.date.created2018-12-14-
dc.date.created2018-12-14-
dc.date.created2018-12-14-
dc.date.issued2018-08-
dc.identifier.citationACS APPLIED MATERIALS & INTERFACES, v.10, no.34, pp.28458 - 28470-
dc.identifier.issn1944-8244-
dc.identifier.urihttp://hdl.handle.net/10203/248768-
dc.description.abstractCurcumin (CRC) has been widely used as a therapeutic agent for various drug delivery applications. In this work, we focused on the applicability of CRC as a nanodrug delivery agent for doxorubicin hydrochloride (DOX) (commercially known as Adriamycin) coated with poly(ethylene glycol) (PEG) as an effective therapeutic strategy against multidrug-resistant cancer cells. The developed PEG-coated CRC/DOX nanoparticles (NPs) (PEG-CRC/DOX NPs) were well localized within the resistant cancer cells inducing apoptosis confirmed by flow cytometry and DNA fragmentation assays. The PEG-CRC/DOX NPs suppressed the major efflux proteins in DOX-resistant cancer cells. The in vivo biodistribution studies on HCT-8/DOX-resistant tumor xenograft showed improved bioavailability of the PEG-CRC/DOX NPs, and thereby suppressed tumor growth significantly compared to the other samples. This study clearly shows that curcumin nanoparticles could deliver DOX efficiently into the multidrug-resistant cancer cells to have potential therapeutic benefits. © 2018 American Chemical Society.-
dc.languageEnglish-
dc.publisherAMER CHEMICAL SOC-
dc.titleCurcumin as a Novel Nanocarrier System for Doxorubicin Delivery to MDR Cancer Cells: In Vitro and in Vivo Evaluation-
dc.typeArticle-
dc.identifier.wosid000443654600023-
dc.identifier.scopusid2-s2.0-85052812745-
dc.type.rimsART-
dc.citation.volume10-
dc.citation.issue34-
dc.citation.beginningpage28458-
dc.citation.endingpage28470-
dc.citation.publicationnameACS APPLIED MATERIALS & INTERFACES-
dc.identifier.doi10.1021/acsami.8b10426-
dc.contributor.localauthorJon, Sangyong-
dc.contributor.localauthorKim, Yeu-Chun-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorcurcumin-
dc.subject.keywordAuthordoxorubicin-
dc.subject.keywordAuthorIn vivo tumor suppression-
dc.subject.keywordAuthorMDR-
dc.subject.keywordAuthorp-glycoprotein-
dc.subject.keywordAuthorMDR-
dc.subject.keywordAuthorp-glycoprotein-
dc.subject.keywordAuthorcurcumin-
dc.subject.keywordAuthordoxorubicin-
dc.subject.keywordAuthorIn vivo tumor suppression-
dc.subject.keywordPlusBiochemistry-
dc.subject.keywordPlusCell death-
dc.subject.keywordPlusControlled drug delivery-
dc.subject.keywordPlusGlycoproteins-
dc.subject.keywordPlusNanoparticles-
dc.subject.keywordPlusPolyethylene glycols-
dc.subject.keywordPlusTargeted drug delivery-
dc.subject.keywordPlusTumors-
dc.subject.keywordPlusCurcumin-
dc.subject.keywordPlusDoxorubicin-
dc.subject.keywordPlusDoxorubicin hydrochloride-
dc.subject.keywordPlusDrug delivery applications-
dc.subject.keywordPlusMultidrug-resistant cancer cells-
dc.subject.keywordPlusP-glycoprotein-
dc.subject.keywordPlusTherapeutic benefits-
dc.subject.keywordPlusTumor suppression-
dc.subject.keywordPlusDiseases-
dc.subject.keywordPlusP-GLYCOPROTEIN EXPRESSION-
dc.subject.keywordPlusSOLID TUMORS-
dc.subject.keywordPlusCO-DELIVERY-
dc.subject.keywordPlusPENETRATING PEPTIDE-
dc.subject.keywordPlusDRUG NANOCRYSTALS-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusRESISTANCE-
dc.subject.keywordPlusADRIAMYCIN-
dc.subject.keywordPlusMECHANISM-
dc.subject.keywordPlusTHERAPY-
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BS-Journal Papers(저널논문)CBE-Journal Papers(저널논문)
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