Metal-free, visible-light-induced site-selective heteroarylation of remote C(sp3)−H bonds has been accomplished through the design of N-alkoxyheteroarenium salts serving as both alkoxy radical precursors and heteroaryl sources. The transient alkoxy radical can be generated by the single-electron reduction of an N-alkoxypyridinium substrate by a photoexcited quinolinone catalyst. Subsequent radical translocation of the alkoxy radical forms a nucleophilic alkyl radical intermediate, which undergoes addition to the substrate to achieve remote C(sp3)−H heteroarylation. This cascade strategy provides a powerful platform for remote C(sp3)−H heteroarylation in a controllable and selective manner and is well suited for late-stage functionalization of complex bioactive molecules.