DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, A. Reum | ko |
dc.contributor.author | Park, Junsik | ko |
dc.contributor.author | Kim, Jong Hoon | ko |
dc.contributor.author | Kwak, Jeongeun | ko |
dc.contributor.author | Cho, Youngran | ko |
dc.contributor.author | Lee, Hyojin | ko |
dc.contributor.author | Jeong, Moonsup | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2018-11-22T07:08:09Z | - |
dc.date.available | 2018-11-22T07:08:09Z | - |
dc.date.created | 2018-11-19 | - |
dc.date.created | 2018-11-19 | - |
dc.date.created | 2018-11-19 | - |
dc.date.created | 2018-11-19 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.citation | IMMUNE NETWORK, v.18, no.5 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | http://hdl.handle.net/10203/246902 | - |
dc.description.abstract | Herpes zoster (HZ), or shingles, is caused by the reactivation of latent varicella-zoster virus (VZV) from the sensory ganglia when VZV-specific T-cell immunity is decreased because of aging or immunosuppression. In the present study, we developed HZ DNA vaccine candidates encoding VZV proteins and cytokine adjuvants, such as IL-7 and IL-33. We immunized C57BL/6 mice with DNA plasmids encoding VZV glycoprotein E (gE), immediate early (IE) 63, or IE62 proteins and found that robust VZV protein-specific T-cell responses were elicited by HZ DNA vaccination. Co-administration of DNA plasmids encoding IL-7 or IL-33 in HZ DNA vaccination significantly enhanced the magnitude of VZV proteinspecific T-cell responses. Protective immunity elicited by HZ DNA vaccination was proven by challenge experiments with a surrogate virus, vaccinia virus expressing gE (VV-gE). A single dose of HZ DNA vaccine strongly boosted gE-specific T-cell responses in mice with a history of previous infection by VV-gE. Thus, HZ DNA vaccines with IL-7 and IL-33 adjuvants strongly elicit protective immunity. | - |
dc.language | English | - |
dc.publisher | KOREA ASSOC IMMUNOLOGISTS | - |
dc.title | Herpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity | - |
dc.type | Article | - |
dc.identifier.wosid | 000449229600006 | - |
dc.identifier.scopusid | 2-s2.0-85059652953 | - |
dc.type.rims | ART | - |
dc.citation.volume | 18 | - |
dc.citation.issue | 5 | - |
dc.citation.publicationname | IMMUNE NETWORK | - |
dc.identifier.doi | 10.4110/in.2018.18.e38 | - |
dc.identifier.kciid | ART002400671 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Cho, Youngran | - |
dc.contributor.nonIdAuthor | Lee, Hyojin | - |
dc.contributor.nonIdAuthor | Jeong, Moonsup | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Herpes zoster | - |
dc.subject.keywordAuthor | T-cells | - |
dc.subject.keywordAuthor | DNA vaccines | - |
dc.subject.keywordAuthor | IL-7 | - |
dc.subject.keywordAuthor | IL-33 | - |
dc.subject.keywordPlus | SUBUNIT VACCINE | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | PHASE 1/2 | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | INTERLEUKIN-7 | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
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