Low-power and low-drug-dose photodynamic chemotherapy via the breakdown of tumor-targeted micelles by reactive oxygen species

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dc.contributor.authorSeah, Geok Lengko
dc.contributor.authorYu, Jeong Heonko
dc.contributor.authorYang, Moon Youngko
dc.contributor.authorKim, Woo Jinko
dc.contributor.authorKim, Jin-Hoko
dc.contributor.authorPark, Keunchilko
dc.contributor.authorCho, Jae-Wooko
dc.contributor.authorKim, Jee Seonko
dc.contributor.authorNam, Yoon Sungko
dc.date.accessioned2018-10-19T00:42:20Z-
dc.date.available2018-10-19T00:42:20Z-
dc.date.created2018-09-27-
dc.date.created2018-09-27-
dc.date.issued2018-09-
dc.identifier.citationJOURNAL OF CONTROLLED RELEASE, v.286, pp.240 - 253-
dc.identifier.issn0168-3659-
dc.identifier.urihttp://hdl.handle.net/10203/246043-
dc.description.abstractTumor-targeted delivery of anticancer agents using nanocarriers has been explored to increase the therapeutic index of cancer chemotherapy. However, only a few nanocarriers are clinically available because the physiological complexity often compromises their ability to target, penetrate, and control the release of drugs. Here, we report a method which dramatically increases in vivo therapeutic drug efficacy levels through the photodynamic degradation of tumor-targeted nanocarriers. Folate-decorated poly(ethylene glycol)-polythioketal micelles are prepared to encapsulate paclitaxel and porphyrins. Photo-excitation generates reactive oxygen species within the micelles to cleave the polythioketal backbone efficiently and facilitate drug release only at the illuminated tumor site. Intravenous injection of a murine xenograft model with a low dose of paclitaxel within the micelles, one-milligram drug per kg (mouse), corresponding to an amount less than that of Taxol by one order of magnitude, induces dramatic tumor regression without any acute systemic inflammation responses or organ toxicity under low-power irradiation (55 mW cm(-2)) at 650 nm.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectNEAR-INFRARED LIGHT-
dc.subjectBLOCK-COPOLYMER MICELLES-
dc.subjectSINGLET-OXYGEN-
dc.subjectPOLYMERIC MICELLES-
dc.subjectHYPERSENSITIVITY REACTIONS-
dc.subjectINTRACELLULAR DELIVERY-
dc.subjectENDO/LYSOSOMAL ESCAPE-
dc.subjectCOMBINATION THERAPY-
dc.subjectGENE DELIVERY-
dc.subjectCELL LINES-
dc.titleLow-power and low-drug-dose photodynamic chemotherapy via the breakdown of tumor-targeted micelles by reactive oxygen species-
dc.typeArticle-
dc.identifier.wosid000444238000023-
dc.identifier.scopusid2-s2.0-85050851437-
dc.type.rimsART-
dc.citation.volume286-
dc.citation.beginningpage240-
dc.citation.endingpage253-
dc.citation.publicationnameJOURNAL OF CONTROLLED RELEASE-
dc.identifier.doi10.1016/j.jconrel.2018.07.046-
dc.contributor.localauthorNam, Yoon Sung-
dc.contributor.nonIdAuthorYang, Moon Young-
dc.contributor.nonIdAuthorKim, Woo Jin-
dc.contributor.nonIdAuthorKim, Jin-Ho-
dc.contributor.nonIdAuthorPark, Keunchil-
dc.contributor.nonIdAuthorCho, Jae-Woo-
dc.contributor.nonIdAuthorKim, Jee Seon-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorPhotodynamic chemotherapy-
dc.subject.keywordAuthorReactive oxygen species (ROS)-sensitive-
dc.subject.keywordAuthorCancer-targeting-
dc.subject.keywordAuthorPolythioketal-
dc.subject.keywordAuthorLight-induced degradation-
dc.subject.keywordPlusNEAR-INFRARED LIGHT-
dc.subject.keywordPlusBLOCK-COPOLYMER MICELLES-
dc.subject.keywordPlusSINGLET-OXYGEN-
dc.subject.keywordPlusPOLYMERIC MICELLES-
dc.subject.keywordPlusHYPERSENSITIVITY REACTIONS-
dc.subject.keywordPlusINTRACELLULAR DELIVERY-
dc.subject.keywordPlusENDO/LYSOSOMAL ESCAPE-
dc.subject.keywordPlusCOMBINATION THERAPY-
dc.subject.keywordPlusGENE DELIVERY-
dc.subject.keywordPlusCELL LINES-
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