Flexible wireless powered drug delivery system for targeted administration on cerebral cortex

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dc.contributor.authorSung, Sang Hyunko
dc.contributor.authorKim, Young Sooko
dc.contributor.authorJoe, Daniel Juhyungko
dc.contributor.authorMun, Beomhoko
dc.contributor.authorYou, Byoung Kukko
dc.contributor.authorKeum, Do Heeko
dc.contributor.authorHahn, Sei Kwangko
dc.contributor.authorBerggren, Magnusko
dc.contributor.authorKim, Daesooko
dc.contributor.authorLee, Keon Jaeko
dc.date.accessioned2018-08-21T04:39:30Z-
dc.date.available2018-08-21T04:39:30Z-
dc.date.created2018-08-20-
dc.date.created2018-08-20-
dc.date.issued2018-09-
dc.identifier.citationNANO ENERGY, v.51, pp.102 - 112-
dc.identifier.issn2211-2855-
dc.identifier.urihttp://hdl.handle.net/10203/245174-
dc.description.abstractThe controlled drug delivery devices helps timely drug administrations and maintenance of effective dose to maximize curing effects with minimal side effects. Application of this technology to various body parts has been limited, especially in organs with curved surface, such as the brain and the eye. Herein, we report a flexible drug delivery microdevice (f-DDM) for controlled administration on the curved organ surface. The unique structure of the f-DDM consists of freestanding gold membranes over the multireservoir array was implemented by reversing the typical fabrication order of the reservoir and sealing membrane. We optimized the design of the f-DDM by a finite element analysis to prevent thermal damage during the laser transfer and the applying current density for reliable drug release through an electrochemical analysis. The wireless power transfer system was applied to f-DDM, which shows stable wirelessly powered operation. The f-DDM was flexible enough to be implantable on the curved cerebral cortex and successfully adopted for delivery of two different chemicals or prevention of seizure activity using an anti-epileptic drug. Our study opens a new avenue for the controlled, region-specific, and combinatorial application of drugs, the key factors for precision medicine.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectIN-VIVO-
dc.subjectELECTRODE ARRAY-
dc.subjectGOLD-
dc.subjectOPTOGENETICS-
dc.subjectCHLORIDE-
dc.subjectRELEASE-
dc.subjectDEVICE-
dc.subjectBIOCOMPATIBILITY-
dc.subjectCLASSIFICATION-
dc.subjectSEIZURES-
dc.titleFlexible wireless powered drug delivery system for targeted administration on cerebral cortex-
dc.typeArticle-
dc.identifier.wosid000440682100012-
dc.identifier.scopusid2-s2.0-85048796931-
dc.type.rimsART-
dc.citation.volume51-
dc.citation.beginningpage102-
dc.citation.endingpage112-
dc.citation.publicationnameNANO ENERGY-
dc.identifier.doi10.1016/j.nanoen.2018.06.015-
dc.contributor.localauthorJoe, Daniel Juhyung-
dc.contributor.localauthorKim, Daesoo-
dc.contributor.localauthorLee, Keon Jae-
dc.contributor.nonIdAuthorSung, Sang Hyun-
dc.contributor.nonIdAuthorKim, Young Soo-
dc.contributor.nonIdAuthorKeum, Do Hee-
dc.contributor.nonIdAuthorHahn, Sei Kwang-
dc.contributor.nonIdAuthorBerggren, Magnus-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorDrug delivery-
dc.subject.keywordAuthorFlexible device-
dc.subject.keywordAuthorImplantable device-
dc.subject.keywordAuthorWireless power transfer-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusELECTRODE ARRAY-
dc.subject.keywordPlusGOLD-
dc.subject.keywordPlusOPTOGENETICS-
dc.subject.keywordPlusCHLORIDE-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordPlusDEVICE-
dc.subject.keywordPlusBIOCOMPATIBILITY-
dc.subject.keywordPlusCLASSIFICATION-
dc.subject.keywordPlusSEIZURES-
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RIMS Journal PapersBS-Journal Papers(저널논문)MS-Journal Papers(저널논문)
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