DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Wook | ko |
dc.contributor.author | Matsika, Spiridoula | ko |
dc.date.accessioned | 2018-08-20T06:49:10Z | - |
dc.date.available | 2018-08-20T06:49:10Z | - |
dc.date.created | 2018-07-25 | - |
dc.date.created | 2018-07-25 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.citation | CHEMPHYSCHEM, v.19, no.13, pp.1568 - 1571 | - |
dc.identifier.issn | 1439-4235 | - |
dc.identifier.uri | http://hdl.handle.net/10203/244671 | - |
dc.description.abstract | Electron transfer (ET) to a pyrimidine base from external moieties is a common step involved in the quenching or repair of the cyclobutane pyrimidine dimer (CPD). In contrast, we present a pathway that is initiated by an ET from a flanking guanine base to a pyrimidine base, leading to the formation of a CPD. We studied a T5mCG sequence with a methylated cytosine and our results demonstrate that the pathway involves the formation of an exciplex and intersystem crossings. This pathway also provides an explanation for why the mutational hot spots are correlated with the methylated CpG sequences, which has been a significant issue in cancer research. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | ULTRAVIOLET-RADIATION | - |
dc.subject | MOLECULAR-DYNAMICS | - |
dc.subject | THYMINE DIMER | - |
dc.subject | SELF-REPAIR | - |
dc.subject | SKIN-CANCER | - |
dc.subject | PHOTODIMERIZATION | - |
dc.subject | 5-METHYLCYTOSINE | - |
dc.subject | CYTOSINE | - |
dc.subject | SUNLIGHT | - |
dc.subject | C5-METHYLATION | - |
dc.title | Photochemical Formation of Cyclobutane Pyrimidine Dimers in DNA through Electron Transfer from a Flanking Base | - |
dc.type | Article | - |
dc.identifier.wosid | 000437731700002 | - |
dc.identifier.scopusid | 2-s2.0-85045921294 | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.issue | 13 | - |
dc.citation.beginningpage | 1568 | - |
dc.citation.endingpage | 1571 | - |
dc.citation.publicationname | CHEMPHYSCHEM | - |
dc.identifier.doi | 10.1002/cphc.201800151 | - |
dc.contributor.localauthor | Lee, Wook | - |
dc.contributor.nonIdAuthor | Matsika, Spiridoula | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | DNA | - |
dc.subject.keywordAuthor | electron transfer | - |
dc.subject.keywordAuthor | exciplex | - |
dc.subject.keywordAuthor | QM | - |
dc.subject.keywordAuthor | MM | - |
dc.subject.keywordAuthor | photochemistry | - |
dc.subject.keywordPlus | ULTRAVIOLET-RADIATION | - |
dc.subject.keywordPlus | MOLECULAR-DYNAMICS | - |
dc.subject.keywordPlus | THYMINE DIMER | - |
dc.subject.keywordPlus | SELF-REPAIR | - |
dc.subject.keywordPlus | SKIN-CANCER | - |
dc.subject.keywordPlus | PHOTODIMERIZATION | - |
dc.subject.keywordPlus | 5-METHYLCYTOSINE | - |
dc.subject.keywordPlus | CYTOSINE | - |
dc.subject.keywordPlus | SUNLIGHT | - |
dc.subject.keywordPlus | C5-METHYLATION | - |
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