Photochemical Formation of Cyclobutane Pyrimidine Dimers in DNA through Electron Transfer from a Flanking Base

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Electron transfer (ET) to a pyrimidine base from external moieties is a common step involved in the quenching or repair of the cyclobutane pyrimidine dimer (CPD). In contrast, we present a pathway that is initiated by an ET from a flanking guanine base to a pyrimidine base, leading to the formation of a CPD. We studied a T5mCG sequence with a methylated cytosine and our results demonstrate that the pathway involves the formation of an exciplex and intersystem crossings. This pathway also provides an explanation for why the mutational hot spots are correlated with the methylated CpG sequences, which has been a significant issue in cancer research.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2018-07
Language
English
Article Type
Article
Keywords

ULTRAVIOLET-RADIATION; MOLECULAR-DYNAMICS; THYMINE DIMER; SELF-REPAIR; SKIN-CANCER; PHOTODIMERIZATION; 5-METHYLCYTOSINE; CYTOSINE; SUNLIGHT; C5-METHYLATION

Citation

CHEMPHYSCHEM, v.19, no.13, pp.1568 - 1571

ISSN
1439-4235
DOI
10.1002/cphc.201800151
URI
http://hdl.handle.net/10203/244671
Appears in Collection
RIMS Journal Papers
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