Current state and applications of microbial genome-scale metabolic models

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 51
  • Download : 0
Genome-scale metabolic models (GEMs) are valuable in describing an organism's entire metabolism using genomic information and have made huge impact on systems biology and metabolic engineering. Here we review current state of microbial GEMs and their use in various applications. There has recently been much interest in reconstructing GEMs for microbial communities, reflecting the increasing importance of microbiome. Analyses of recent work suggest that the GEMs for the best studied microorganisms, new or less studied microorganisms, and also microbial communities need to be thoroughly validated with experimental data beyond simple gene essentiality and nutrient utilization capabilities. In this paper, computational modeling resources and frameworks developed recently for reconstructing GEMs of microorganisms and microbial communities together with their applications are reviewed.
Publisher
Elsevier Ltd
Issue Date
2017-04
Language
English
Article Type
Review
Keywords

human; microbial community; microbial genome; microbiome; nonhuman; nutrient

Citation

Current Opinion in Systems Biology, v.2, pp.10 - 18

ISSN
2452-3100
DOI
10.1016/j.coisb.2017.03.001
URI
http://hdl.handle.net/10203/244094
Appears in Collection
CBE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0