DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Eun Ji | ko |
dc.contributor.author | Lee, Daeyong | ko |
dc.contributor.author | Kang, Han Chang | ko |
dc.contributor.author | Kim, Yeu-Chun | ko |
dc.contributor.author | Shim, Min Suk | ko |
dc.date.accessioned | 2018-07-24T02:21:13Z | - |
dc.date.available | 2018-07-24T02:21:13Z | - |
dc.date.created | 2018-07-04 | - |
dc.date.created | 2018-07-04 | - |
dc.date.created | 2018-07-04 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.citation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.63, pp.57 - 64 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | http://hdl.handle.net/10203/243995 | - |
dc.description.abstract | Pro-oxidant therapy utilizing pro-oxidant drugs that can induce cytotoxic oxidative stress in cancer cells has attracted widespread attention for cancer-specific therapy. Piperlongumine (PL) has gained great interest as a novel pro-oxidant agent because it can exhibit cancer-specific cytotoxicity via elevation of intracellular reactive oxygen species (ROS) in cancer cells. However, its therapeutic efficacy has been limited by its poor water-solubility, which necessitates developing suitable drug carriers for PL delivery. In this study, low-toxic poly(ethylene glycol)-poly(histidine) [PEG-poly(His)] copolymer was developed for effective intracellular delivery of PL. Stable micelles composed of a PEG shell and a poly(His) core encapsulating PL were prepared. In vitro study revealed that plain PEG-poly(His) micelles without PL were low-toxic. Importantly, PL-PEG-poly(His) micelles showed superior cytotoxicity in cancer cells over normal cells due to the PL-induced, dramatic increase of intracellular ROS in cancer cells in comparison with normal cells. PL-PEG-poly(His) micelles were further modified with folic acid (FA) to enhance their cancer-specific pro-oxidant therapy. As compared to FA-free micelles, FA-PL-PEG-poly(His) micelles revealed more facilitated cellular uptake and anticancer efficacy in folate receptor-positive cancer cells. This study demonstrates that PL-PEG-poly(His) micelles are efficient and low-toxic carriers for PL delivery, thus leading to effective and cancer-targeted pro-oxidant therapy. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Cancer-specific pro-oxidant therapy using low-toxic polypeptide micelles encapsulating piperlongumine | - |
dc.type | Article | - |
dc.identifier.wosid | 000434001000008 | - |
dc.identifier.scopusid | 2-s2.0-85042262358 | - |
dc.type.rims | ART | - |
dc.citation.volume | 63 | - |
dc.citation.beginningpage | 57 | - |
dc.citation.endingpage | 64 | - |
dc.citation.publicationname | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.identifier.doi | 10.1016/j.jiec.2018.01.040 | - |
dc.contributor.localauthor | Kim, Yeu-Chun | - |
dc.contributor.nonIdAuthor | Hong, Eun Ji | - |
dc.contributor.nonIdAuthor | Kang, Han Chang | - |
dc.contributor.nonIdAuthor | Shim, Min Suk | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Poly(histidine) | - |
dc.subject.keywordAuthor | Micelle | - |
dc.subject.keywordAuthor | Piperlongumine | - |
dc.subject.keywordAuthor | Cancer therapy | - |
dc.subject.keywordAuthor | Pro-oxidant therapy | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | COPOLYMER MICELLES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | ROS | - |
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