Predictors of mortality in Middle East respiratory syndrome (MERS)

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We evaluated the clinical characteristics, cytokine/chemokine concentrations, viral shedding and antibody kinetics in 30 patients with Middle East respiratory syndrome (MERS), including 6 non-survivors admitted to 3 MERS-designated hospitals. Old age, low albumin, altered mentality and high pneumonia severity index score at admission were risk factors for mortality. In addition, severe signs of inflammation at initial presentation (at hospital days 1-4), such as high inducible protein-10 (p=0.0013), monocyte chemoattractant protein-1 (p=0.0007) and interleukin 6 (p=0.0007) concentrations, and poor viral control (high viral load at hospital days 5-10, p<0.001) without adequate antibody titres (low antibody titre at hospital days 11-16, p=0.07) during the course of disease, were associated with mortality.
Publisher
BMJ PUBLISHING GROUP
Issue Date
2018-03
Language
English
Article Type
Letter
Citation

THORAX, v.73, no.3, pp.286 - 289

ISSN
0040-6376
DOI
10.1136/thoraxjnl-2016-209313
URI
http://hdl.handle.net/10203/242285
Appears in Collection
MSE-Journal Papers(저널논문)
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