DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Bo Am | ko |
dc.contributor.author | Lee, Jung-Ha | ko |
dc.contributor.author | Kim, Ho Min | ko |
dc.contributor.author | Kang, Myoung-Goo | ko |
dc.date.accessioned | 2018-05-24T02:25:00Z | - |
dc.date.available | 2018-05-24T02:25:00Z | - |
dc.date.created | 2018-05-08 | - |
dc.date.created | 2018-05-08 | - |
dc.date.created | 2018-05-08 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.498, no.3, pp.402 - 408 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/242269 | - |
dc.description.abstract | Voltage-activated Ca2+ channels (Ca-v) play critical roles in excitable cells including neurons. Unlike the well-defined roles of Ca(v)2 for pre-synaptic neurotransmission, the post-synaptic function of Ca(v)2 is unclear. Based on our previous study demonstrating the postsynaptic association of the Ca(v)2 with the AMPA receptor (AMPA-R), in this study we sought to further analyse the Ca(v)2-AMPA-R association. We used a step-by-step dissociation of partially purified native Ca(v)2-AMPA-R complexes and co-immunoprecipitation of the Ca(v)2-AMPA-R complexes expressed in HEK293T cells to demonstrate that the main subunit of Ca-v, alpha(1), formed a complex with the AMPA-R without the auxiliary subunits beta, alpha(2)delta, gamma(2/3). The alpha(1) subunit increased the cell-surface localisation of the AMPA-R, which could be a post-synaptic function of the Ca(v)2. (C) 2018 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | GATED CA2+ CHANNELS | - |
dc.subject | GAMMA-SUBUNIT | - |
dc.subject | STARGAZIN | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | EXPRESSION | - |
dc.subject | MEMBRANE | - |
dc.subject | BINDING | - |
dc.subject | PSD-95 | - |
dc.subject | MOUSE | - |
dc.subject | SITE | - |
dc.title | Neuronal calcium channel alpha(1) subunit interacts with AMPA receptor, increasing its cell surface localisation | - |
dc.type | Article | - |
dc.identifier.wosid | 000430640500005 | - |
dc.identifier.scopusid | 2-s2.0-85042929370 | - |
dc.type.rims | ART | - |
dc.citation.volume | 498 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 402 | - |
dc.citation.endingpage | 408 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.02.107 | - |
dc.contributor.localauthor | Kim, Ho Min | - |
dc.contributor.nonIdAuthor | Lee, Jung-Ha | - |
dc.contributor.nonIdAuthor | Kang, Myoung-Goo | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Calcium channel | - |
dc.subject.keywordAuthor | Glutamate receptor | - |
dc.subject.keywordAuthor | AMPA receptor | - |
dc.subject.keywordAuthor | Synaptic plasticity | - |
dc.subject.keywordAuthor | On channel | - |
dc.subject.keywordAuthor | Calcium channel subunit | - |
dc.subject.keywordPlus | GATED CA2+ CHANNELS | - |
dc.subject.keywordPlus | GAMMA-SUBUNIT | - |
dc.subject.keywordPlus | STARGAZIN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | PSD-95 | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | SITE | - |
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