SALM/Lrfn Family Synaptic Adhesion Molecules

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dc.contributor.authorLie, Eunkyungko
dc.contributor.authorLi, Yanko
dc.contributor.authorKim, Ryunheeko
dc.contributor.authorKim, Eunjoonko
dc.date.accessioned2018-04-24T06:32:47Z-
dc.date.available2018-04-24T06:32:47Z-
dc.date.created2018-04-18-
dc.date.created2018-04-18-
dc.date.created2018-04-18-
dc.date.created2018-04-18-
dc.date.issued2018-04-
dc.identifier.citationFRONTIERS IN MOLECULAR NEUROSCIENCE, v.11-
dc.identifier.issn1662-5099-
dc.identifier.urihttp://hdl.handle.net/10203/241409-
dc.description.abstractSynaptic adhesion-like molecules (SALMs) are a family of cell adhesion molecules involved in regulating neuronal and synapse development that have also been implicated in diverse brain dysfunctions, including autism spectrum disorders (ASDs). SALMs, also known as leucine-rich repeat (LRR) and fibronectin III domain-containing (LRFN) proteins, were originally identified as a group of novel adhesion-like molecules that contain LRRs in the extracellular region as well as a PDZ domain-binding tail that couples to PSD-95, an abundant excitatory postsynaptic scaffolding protein. While studies over the last decade have steadily explored the basic properties and synaptic and neuronal functions of SALMs, a number of recent studies have provided novel insights into molecular, structural, functional and clinical aspects of SALMs. Here we summarize these findings and discuss how SALMs act in concert with other synaptic proteins to regulate synapse development and function.-
dc.languageEnglish-
dc.publisherFRONTIERS MEDIA SA-
dc.subjectPROTEIN-TYROSINE-PHOSPHATASE-
dc.subjectACTIN CYTOSKELETON REORGANIZATION-
dc.subjectPOSTSYNAPTIC DENSITY PROTEINS-
dc.subjectAUTISM SPECTRUM DISORDERS-
dc.subjectEXCITATORY SYNAPSES-
dc.subjectPTP-SIGMA-
dc.subjectTRANSSYNAPTIC INTERACTION-
dc.subjectINTELLECTUAL DISABILITY-
dc.subjectGLUTAMATE RECEPTORS-
dc.subjectHIPPOCAMPAL-NEURONS-
dc.titleSALM/Lrfn Family Synaptic Adhesion Molecules-
dc.typeArticle-
dc.identifier.wosid000429259400001-
dc.identifier.scopusid2-s2.0-85046884906-
dc.type.rimsART-
dc.citation.volume11-
dc.citation.publicationnameFRONTIERS IN MOLECULAR NEUROSCIENCE-
dc.identifier.doi10.3389/fnmol.2018.00105-
dc.contributor.localauthorKim, Eunjoon-
dc.contributor.nonIdAuthorLie, Eunkyung-
dc.contributor.nonIdAuthorLi, Yan-
dc.description.isOpenAccessY-
dc.type.journalArticleReview-
dc.subject.keywordAuthoradhesion molecules-
dc.subject.keywordAuthorsynaptic-
dc.subject.keywordAuthorSALM-
dc.subject.keywordAuthorLrfn-
dc.subject.keywordAuthorPSD-95-
dc.subject.keywordAuthoradhesion molecules-
dc.subject.keywordAuthorsynaptic-
dc.subject.keywordAuthorSALM-
dc.subject.keywordAuthorLrfn-
dc.subject.keywordAuthorPSD-95-
dc.subject.keywordPlusPROTEIN-TYROSINE-PHOSPHATASE-
dc.subject.keywordPlusACTIN CYTOSKELETON REORGANIZATION-
dc.subject.keywordPlusPOSTSYNAPTIC DENSITY PROTEINS-
dc.subject.keywordPlusAUTISM SPECTRUM DISORDERS-
dc.subject.keywordPlusEXCITATORY SYNAPSES-
dc.subject.keywordPlusPTP-SIGMA-
dc.subject.keywordPlusTRANSSYNAPTIC INTERACTION-
dc.subject.keywordPlusINTELLECTUAL DISABILITY-
dc.subject.keywordPlusGLUTAMATE RECEPTORS-
dc.subject.keywordPlusHIPPOCAMPAL-NEURONS-
dc.subject.keywordPlusPROTEIN-TYROSINE-PHOSPHATASE-
dc.subject.keywordPlusACTIN CYTOSKELETON REORGANIZATION-
dc.subject.keywordPlusPOSTSYNAPTIC DENSITY PROTEINS-
dc.subject.keywordPlusAUTISM SPECTRUM DISORDERS-
dc.subject.keywordPlusEXCITATORY SYNAPSES-
dc.subject.keywordPlusPTP-SIGMA-
dc.subject.keywordPlusTRANSSYNAPTIC INTERACTION-
dc.subject.keywordPlusINTELLECTUAL DISABILITY-
dc.subject.keywordPlusGLUTAMATE RECEPTORS-
dc.subject.keywordPlusHIPPOCAMPAL-NEURONS-
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