SALM/Lrfn Family Synaptic Adhesion Molecules

Cited 6 time in webofscience Cited 0 time in scopus
  • Hit : 127
  • Download : 3
Synaptic adhesion-like molecules (SALMs) are a family of cell adhesion molecules involved in regulating neuronal and synapse development that have also been implicated in diverse brain dysfunctions, including autism spectrum disorders (ASDs). SALMs, also known as leucine-rich repeat (LRR) and fibronectin III domain-containing (LRFN) proteins, were originally identified as a group of novel adhesion-like molecules that contain LRRs in the extracellular region as well as a PDZ domain-binding tail that couples to PSD-95, an abundant excitatory postsynaptic scaffolding protein. While studies over the last decade have steadily explored the basic properties and synaptic and neuronal functions of SALMs, a number of recent studies have provided novel insights into molecular, structural, functional and clinical aspects of SALMs. Here we summarize these findings and discuss how SALMs act in concert with other synaptic proteins to regulate synapse development and function.
Publisher
FRONTIERS MEDIA SA
Issue Date
2018-04
Language
English
Article Type
Review
Keywords

PROTEIN-TYROSINE-PHOSPHATASE; ACTIN CYTOSKELETON REORGANIZATION; POSTSYNAPTIC DENSITY PROTEINS; AUTISM SPECTRUM DISORDERS; EXCITATORY SYNAPSES; PTP-SIGMA; TRANSSYNAPTIC INTERACTION; INTELLECTUAL DISABILITY; GLUTAMATE RECEPTORS; HIPPOCAMPAL-NEURONS

Citation

FRONTIERS IN MOLECULAR NEUROSCIENCE, v.11

ISSN
1662-5099
DOI
10.3389/fnmol.2018.00105
URI
http://hdl.handle.net/10203/241409
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
000429259400001.pdf(2.4 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 6 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0