Synthesis, characterization of ZnO-chitosan nanocomposites and evaluation of its antifungal activity against pathogenic Candida albicans

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In this study, we investigated the antifungal activity and cytotoxicity of ZnO-chitosan nanocomposites (ZnO-C NCs) against Candida albicans and human epithelial type 2 (HEp2) cells, respectively. The crystalline phase, morphology, composition, particle size and optical absorption properties of the synthesized ZnO-C NCs were systematically investigated by various contemporary methods. The X-ray diffraction analysis results showed characteristic diffraction peaks corresponding to both ZnO and chitosan, while field-emission scanning electron microscopy (FESEM) displayed clusters of spherical shaped particulate morphology. UV vis absorption spectra showed a shift in the optical absorption towards lower wavelength for ZnO-C NCs when compared to ZnO nanoparticles (NPs). The antifungal activity results (against C. albicans) showed that the minimum inhibitory concentration of ZnO NPs and ZnO-C NCs were 200 mu g/mL and 75 mu g/mL, respectively, suggesting the greater therapeutic potential of ZnO-C NCs. FESEM analysis results showed the substantial change in the external morphology of C. albicans after treatment with both ZnO NPs and ZnO-C NCs due to the fungal cell membrane damage. ZnO-C NCs displayed lower cytotoxicity with HEp2 cells indicating the good cytocompatibility of the synthesized ZnO-C NCs. It is expected that ZnO and chitosan complement each other and exhibit synergistic effects potential for antimicrobial and biomedical applications. (C) 2017 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2018-03
Language
English
Article Type
Article
Keywords

GRAM-POSITIVE BACTERIA; ANTIBACTERIAL PROPERTIES; NANOPARTICLES; FILMS; ENHANCEMENT; NANOWIRES; NPS

Citation

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.108, pp.1281 - 1288

ISSN
0141-8130
DOI
10.1016/j.ijbiomac.2017.11.046
URI
http://hdl.handle.net/10203/240925
Appears in Collection
ME-Journal Papers(저널논문)
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