Four-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release

Cited 13 time in webofscience Cited 0 time in scopus
  • Hit : 226
  • Download : 0
Human ferritins are emerging platforms for nontoxic protein-based drug delivery, owing to their intrinsic or acquirable targeting abilities to cancer cells and hollow cage structures for drug loading. However, reliable strategies for high-level drug encapsulation within ferritin cavities and prompt cellular drug release are still lacking. Ferritin nano-cages were developed with partially opened hydrophobic channels, which provide stable routes for spontaneous and highly accumulated loading of FeII-conjugated drugs as well as pH-responsive rapid drug release at endoplasmic pH. Multiple cancer-related compounds, such as doxorubicin, curcumin, and quercetin, were actively and heavily loaded onto the prepared nicked ferritin. Drugs on these minimally modified ferritins were effectively delivered inside cancer cells with high toxicity.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2018-03
Language
English
Article Type
Article
Citation

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.57, no.11, pp.2909 - 2913

ISSN
1433-7851
DOI
10.1002/anie.201800516
URI
http://hdl.handle.net/10203/240917
Appears in Collection
MSE-Journal Papers(저널논문)CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 13 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0