DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, You-Me | ko |
dc.contributor.author | Brinkmann, Melanie M. | ko |
dc.contributor.author | Paquet, Marie-Eve | ko |
dc.contributor.author | Ploegh, Hidde L. | ko |
dc.date.accessioned | 2018-03-21T02:57:15Z | - |
dc.date.available | 2018-03-21T02:57:15Z | - |
dc.date.created | 2018-03-14 | - |
dc.date.created | 2018-03-14 | - |
dc.date.created | 2018-03-14 | - |
dc.date.issued | 2008-03 | - |
dc.identifier.citation | NATURE, v.452, no.7184, pp.234 - U80 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240853 | - |
dc.description.abstract | Signalling by means of toll- like receptors ( TLRs) is essential for the development of innate and adaptive immune responses(1-3). UNC93B1, essential for signalling of TLR3, TLR7 and TLR9 in both humans and mice, physically interacts with these TLRs in the endoplasmic reticulum ( ER)(4-6). Here we show that the function of the polytopic membrane protein UNC93B1 is to deliver the nucleotide- sensing receptors TLR7 and TLR9 from the ER to endolysosomes. In dendritic cells of 3d mice, which express an UNC93B1 missense mutant ( H412R) incapable of TLR binding, neither TLR7 nor TLR9 exits the ER. Furthermore, the trafficking and signalling defects of the nucleotide- sensing TLRs in 3d dendritic cells are corrected by expression of wild- type UNC93B1. However, UNC93B1 is dispensable for ligand recognition and signal initiation by TLRs. To our knowledge, UNC93B1 is the first protein to be identified as a molecule specifically involved in trafficking of nucleotide- sensing TLRs. By inhibiting the interaction between UNC93B1 and TLRs it should be possible to achieve specific regulation of the nucleotide- sensing TLRs without compromising signalling via the cell- surface- disposed TLRs. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes | - |
dc.type | Article | - |
dc.identifier.wosid | 000253925600044 | - |
dc.identifier.scopusid | 2-s2.0-40749098665 | - |
dc.type.rims | ART | - |
dc.citation.volume | 452 | - |
dc.citation.issue | 7184 | - |
dc.citation.beginningpage | 234 | - |
dc.citation.endingpage | U80 | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/nature06726 | - |
dc.contributor.localauthor | Kim, You-Me | - |
dc.contributor.nonIdAuthor | Brinkmann, Melanie M. | - |
dc.contributor.nonIdAuthor | Paquet, Marie-Eve | - |
dc.contributor.nonIdAuthor | Ploegh, Hidde L. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | CPG-DNA | - |
dc.subject.keywordPlus | SUBCELLULAR-LOCALIZATION | - |
dc.subject.keywordPlus | EXOGENOUS ANTIGEN | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | ER | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | DISTINCT | - |
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