Murine B Cell Response to TLR7 Ligands Depends on an IFN-beta Feedback Loop

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dc.contributor.authorGreen, Nathaniel M.ko
dc.contributor.authorLaws, Amyko
dc.contributor.authorKiefer, Kerstinko
dc.contributor.authorBusconi, Lilianako
dc.contributor.authorKim, You-Meko
dc.contributor.authorBrinkmann, Melanie M.ko
dc.contributor.authorTrail, Erin Hodgesko
dc.contributor.authorYasuda, Keiko
dc.contributor.authorChristensen, Sean R.ko
dc.contributor.authorShlomchik, Mark J.ko
dc.contributor.authorVogel, Stefanieko
dc.contributor.authorConnor, John H.ko
dc.contributor.authorPloegh, Hiddeko
dc.contributor.authorEilat, Danko
dc.contributor.authorRifkin, Ian R.ko
dc.contributor.authorvan Seventer, Jean Maguireko
dc.contributor.authorMarshak-Rothstein, Annko
dc.date.accessioned2018-03-21T02:57:07Z-
dc.date.available2018-03-21T02:57:07Z-
dc.date.created2018-03-14-
dc.date.created2018-03-14-
dc.date.issued2009-08-
dc.identifier.citationJOURNAL OF IMMUNOLOGY, v.183, no.3, pp.1569 - 1576-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10203/240848-
dc.description.abstractType I IFNs play an important, yet poorly characterized, role in systemic lupus erythematosus. To better understand the interplay between type I IFNs and the activation of autoreactive B cells, we evaluated the effect of type I IFN receptor (IFNAR) deficiency in murine B cell responses to common TLR ligands. In comparison to wild-type B cells, TLR7-stimulated IFNAR(-/-) B cells proliferated significantly less well and did not up-regulate costimulatory molecules. By contrast, IFNAR1(-/-) B cells did not produce cytokines, but did proliferate and up-regulate activation markers in response to other TLR ligands. These defects were not due to a difference in the distribution of B cell populations or a failure to produce a soluble factor other than a type I IFN. Instead, the compromised response pattern reflected the disruption of an IFN-beta feedback loop and constitutively low expression of TLR7 in the IFNAR1(-/-) B cells. These results highlight subtle differences in the IFN dependence of TLR7 responses compared with other TLR-mediated B cell responses. The Journal of Immunology, 2009, 183: 1569-1576.-
dc.languageEnglish-
dc.publisherAMER ASSOC IMMUNOLOGISTS-
dc.subjectSYSTEMIC-LUPUS-ERYTHEMATOSUS-
dc.subjectI INTERFERON RECEPTOR-
dc.subjectTOLL-LIKE RECEPTORS-
dc.subjectPLASMACYTOID DENDRITIC CELLS-
dc.subjectMEDIATED ENHANCEMENT-
dc.subjectIMMUNE-COMPLEXES-
dc.subjectALPHA PRODUCTION-
dc.subjectMICE-
dc.subjectACTIVATION-
dc.subjectDISEASE-
dc.titleMurine B Cell Response to TLR7 Ligands Depends on an IFN-beta Feedback Loop-
dc.typeArticle-
dc.identifier.wosid000268519500012-
dc.identifier.scopusid2-s2.0-68149126174-
dc.type.rimsART-
dc.citation.volume183-
dc.citation.issue3-
dc.citation.beginningpage1569-
dc.citation.endingpage1576-
dc.citation.publicationnameJOURNAL OF IMMUNOLOGY-
dc.identifier.doi10.4049/jimmunol.0803899-
dc.contributor.localauthorKim, You-Me-
dc.contributor.nonIdAuthorGreen, Nathaniel M.-
dc.contributor.nonIdAuthorLaws, Amy-
dc.contributor.nonIdAuthorKiefer, Kerstin-
dc.contributor.nonIdAuthorBusconi, Liliana-
dc.contributor.nonIdAuthorBrinkmann, Melanie M.-
dc.contributor.nonIdAuthorTrail, Erin Hodges-
dc.contributor.nonIdAuthorYasuda, Kei-
dc.contributor.nonIdAuthorChristensen, Sean R.-
dc.contributor.nonIdAuthorShlomchik, Mark J.-
dc.contributor.nonIdAuthorVogel, Stefanie-
dc.contributor.nonIdAuthorConnor, John H.-
dc.contributor.nonIdAuthorPloegh, Hidde-
dc.contributor.nonIdAuthorEilat, Dan-
dc.contributor.nonIdAuthorRifkin, Ian R.-
dc.contributor.nonIdAuthorvan Seventer, Jean Maguire-
dc.contributor.nonIdAuthorMarshak-Rothstein, Ann-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusSYSTEMIC-LUPUS-ERYTHEMATOSUS-
dc.subject.keywordPlusI INTERFERON RECEPTOR-
dc.subject.keywordPlusTOLL-LIKE RECEPTORS-
dc.subject.keywordPlusPLASMACYTOID DENDRITIC CELLS-
dc.subject.keywordPlusMEDIATED ENHANCEMENT-
dc.subject.keywordPlusIMMUNE-COMPLEXES-
dc.subject.keywordPlusALPHA PRODUCTION-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusDISEASE-
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