Crucial Roles of Interleukin-7 in the Development of T Follicular Helper Cells and in the Induction of Humoral Immunity

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dc.contributor.authorSeo, Yong Bokko
dc.contributor.authorIm, Se Jinko
dc.contributor.authorNamkoong, Hongko
dc.contributor.authorKim, Sae Wonko
dc.contributor.authorChoi, Young Wooko
dc.contributor.authorKang, Moon Cheolko
dc.contributor.authorLim, Hye Seongko
dc.contributor.authorJin, Hyun Takko
dc.contributor.authorYang, Se Hwanko
dc.contributor.authorCho, Mi Lako
dc.contributor.authorKim, You-Meko
dc.contributor.authorLee, Seung-Wooko
dc.contributor.authorChoi, Young Kiko
dc.contributor.authorSurh, Charles D.ko
dc.contributor.authorSung, Young Chulko
dc.date.accessioned2018-03-21T02:53:42Z-
dc.date.available2018-03-21T02:53:42Z-
dc.date.created2018-03-14-
dc.date.created2018-03-14-
dc.date.issued2014-08-
dc.identifier.citationJOURNAL OF VIROLOGY, v.88, no.16, pp.8998 - 9009-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10203/240788-
dc.description.abstractT follicular helper (Tfh) cells are specialized providers of cognate B cell help, which is important in promoting the induction of high-affinity antibody production in germinal centers (GCs). Interleukin-6 (IL-6) and IL-21 have been known to play important roles in Tfh cell differentiation. Here, we demonstrate that IL-7 plays a pivotal role in Tfh generation and GC formation in vivo, as treatment with anti-IL-7 neutralizing antibody markedly impaired the development of Tfh cells and IgG responses. Moreover, codelivery of mouse Fc-fused IL-7 (IL-7-mFc) with a vaccine enhanced the generation of GC B cells as well as Tfh cells but not other lineages of T helper cells, including Th1, Th2, and Th17 cells. Interestingly, a 6-fold-lower dose of an influenza virus vaccine codelivered with Fc-fused IL-7 induced higher antigen-specific and cross-reactive IgG titers than the vaccine alone in both mice and monkeys and led to markedly enhanced protection against heterologous influenza virus challenge in mice. Enhanced generation of Tfh cells by IL-7-mFc treatment was not significantly affected by the neutralization of IL-6 and IL-21, indicating an independent role of IL-7 on Tfh differentiation. Thus, IL-7 holds promise as a critical cytokine for selectively inducing Tfh cell generation and enhancing protective IgG responses.-
dc.languageEnglish-
dc.publisherAMER SOC MICROBIOLOGY-
dc.subjectDENDRITIC CELLS-
dc.subjectGERMINAL-CENTERS-
dc.subjectIN-VIVO-
dc.subjectDIFFERENTIATION-
dc.subjectGENERATION-
dc.subjectADJUVANT-
dc.subjectBCL6-
dc.subjectINFECTION-
dc.subjectEXPANSION-
dc.subjectCYTOKINES-
dc.titleCrucial Roles of Interleukin-7 in the Development of T Follicular Helper Cells and in the Induction of Humoral Immunity-
dc.typeArticle-
dc.identifier.wosid000340036800023-
dc.identifier.scopusid2-s2.0-84904893638-
dc.type.rimsART-
dc.citation.volume88-
dc.citation.issue16-
dc.citation.beginningpage8998-
dc.citation.endingpage9009-
dc.citation.publicationnameJOURNAL OF VIROLOGY-
dc.identifier.doi10.1128/JVI.00534-14-
dc.contributor.localauthorKim, You-Me-
dc.contributor.nonIdAuthorSeo, Yong Bok-
dc.contributor.nonIdAuthorIm, Se Jin-
dc.contributor.nonIdAuthorNamkoong, Hong-
dc.contributor.nonIdAuthorKim, Sae Won-
dc.contributor.nonIdAuthorChoi, Young Woo-
dc.contributor.nonIdAuthorKang, Moon Cheol-
dc.contributor.nonIdAuthorLim, Hye Seong-
dc.contributor.nonIdAuthorJin, Hyun Tak-
dc.contributor.nonIdAuthorYang, Se Hwan-
dc.contributor.nonIdAuthorCho, Mi La-
dc.contributor.nonIdAuthorLee, Seung-Woo-
dc.contributor.nonIdAuthorChoi, Young Ki-
dc.contributor.nonIdAuthorSurh, Charles D.-
dc.contributor.nonIdAuthorSung, Young Chul-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusDENDRITIC CELLS-
dc.subject.keywordPlusGERMINAL-CENTERS-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusGENERATION-
dc.subject.keywordPlusADJUVANT-
dc.subject.keywordPlusBCL6-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusEXPANSION-
dc.subject.keywordPlusCYTOKINES-
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