TLR9 regulates adipose tissue inflammation and obesity-related metabolic disorders

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ObjectiveRecent studies have revealed a link between Toll-like receptor (TLR) signaling and the adipose tissue inflammation associated with obesity. Although TLR9 is known to play an important role in inflammation and innate immunity, its role in mediating adipose tissue inflammation has not yet been investigated. Thus, the objective of this study was to determine the role of TLR9 in regulating immune cells in visceral adipose tissue and maintaining the metabolic homeostasis. MethodsWild-type and TLR9-deficient mice were fed with a high-fat diet, and the body weight gain, glucose tolerance, insulin sensitivity, and adipose tissue inflammation were examined. ResultsTLR9-deficient mice gained significantly more weight and body fat under a high-fat diet than wild-type mice and exhibited more severe glucose intolerance and insulin resistance. We also found a dramatic increase of M1 macrophages as well as T(H)1 cells in the adipose tissue of TLR9-deficient mice compared to wild-type mice. Furthermore, the levels of various proinflammatory cytokines and chemokines were higher in TLR9-deficient mice. ConclusionsTLR9 signaling is involved in regulating adipose tissue inflammation and controlling obesity and the metabolic syndrome.
Publisher
WILEY-BLACKWELL
Issue Date
2015-11
Language
English
Article Type
Article
Keywords

DIET-INDUCED OBESITY; INNATE IMMUNE DEFENSE; TOLL-LIKE RECEPTOR-9; INSULIN-RESISTANCE; T-CELLS; MICE; MACROPHAGES; POLARIZATION; RECRUITMENT; HOMEOSTASIS

Citation

OBESITY, v.23, no.11, pp.2199 - 2206

ISSN
1930-7381
DOI
10.1002/oby.21215
URI
http://hdl.handle.net/10203/240770
Appears in Collection
MSE-Journal Papers(저널논문)
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