DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sugawara, Reiko | ko |
dc.contributor.author | Lee, Eun-Jung | ko |
dc.contributor.author | Jang, Min Seong | ko |
dc.contributor.author | Jeun, Eun-Ji | ko |
dc.contributor.author | Hong, Chun-Pyo | ko |
dc.contributor.author | Kim, Jung-Hwan | ko |
dc.contributor.author | Park, Areum | ko |
dc.contributor.author | Yun, Chang Ho | ko |
dc.contributor.author | Hong, Sung-Wook | ko |
dc.contributor.author | Kim, You-Me | ko |
dc.contributor.author | Seoh, Ju-Young | ko |
dc.contributor.author | Jung, YunJae | ko |
dc.contributor.author | Surh, Charles D. | ko |
dc.contributor.author | Miyasaka, Masayuki | ko |
dc.contributor.author | Yang, Bo-Gie | ko |
dc.contributor.author | Jang, Myoung Ho | ko |
dc.date.accessioned | 2018-03-21T02:53:07Z | - |
dc.date.available | 2018-03-21T02:53:07Z | - |
dc.date.created | 2018-03-14 | - |
dc.date.created | 2018-03-14 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | JOURNAL OF EXPERIMENTAL MEDICINE, v.213, no.4, pp.555 - 567 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240765 | - |
dc.description.abstract | Eosinophils play proinflammatory roles in helminth infections and allergic diseases. Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. In this study, we found that small intestinal eosinophils down-regulate Th17 cells. Th17 cells in the small intestine were markedly increased in the Delta dblGATA-1 mice lacking eosinophils, and an inverse correlation was observed between the number of eosinophils and that of Th17 cells in the small intestine of wild-type mice. In addition, small intestinal eosinophils suppressed the in vitro differentiation of Th17 cells, as well as IL-17 production by small intestinal CD4(+) T cells. Unlike other small intestinal immune cells or circulating eosinophils, we found that small intestinal eosinophils have a unique ability to constitutively secrete high levels of IL-1 receptor antagonist (IL-1Ra), a natural inhibitor of IL-1 beta. Moreover, small intestinal eosinophils isolated from IL-1Ra-deficient mice failed to suppress Th17 cells. Collectively, our results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra. | - |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.subject | COLONY-STIMULATING FACTOR | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | T(H)17 CELLS | - |
dc.subject | GM-CSF | - |
dc.subject | GASTROINTESTINAL-TRACT | - |
dc.subject | AIRWAY INFLAMMATION | - |
dc.subject | IMMUNE HOMEOSTASIS | - |
dc.subject | T-CELLS | - |
dc.subject | IN-VIVO | - |
dc.subject | MICE | - |
dc.title | Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist | - |
dc.type | Article | - |
dc.identifier.wosid | 000373394100008 | - |
dc.identifier.scopusid | 2-s2.0-84995455338 | - |
dc.type.rims | ART | - |
dc.citation.volume | 213 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 555 | - |
dc.citation.endingpage | 567 | - |
dc.citation.publicationname | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.identifier.doi | 10.1084/jem.20141388 | - |
dc.contributor.localauthor | Kim, You-Me | - |
dc.contributor.nonIdAuthor | Sugawara, Reiko | - |
dc.contributor.nonIdAuthor | Lee, Eun-Jung | - |
dc.contributor.nonIdAuthor | Jang, Min Seong | - |
dc.contributor.nonIdAuthor | Jeun, Eun-Ji | - |
dc.contributor.nonIdAuthor | Hong, Chun-Pyo | - |
dc.contributor.nonIdAuthor | Kim, Jung-Hwan | - |
dc.contributor.nonIdAuthor | Park, Areum | - |
dc.contributor.nonIdAuthor | Yun, Chang Ho | - |
dc.contributor.nonIdAuthor | Hong, Sung-Wook | - |
dc.contributor.nonIdAuthor | Seoh, Ju-Young | - |
dc.contributor.nonIdAuthor | Jung, YunJae | - |
dc.contributor.nonIdAuthor | Surh, Charles D. | - |
dc.contributor.nonIdAuthor | Miyasaka, Masayuki | - |
dc.contributor.nonIdAuthor | Yang, Bo-Gie | - |
dc.contributor.nonIdAuthor | Jang, Myoung Ho | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | T(H)17 CELLS | - |
dc.subject.keywordPlus | GM-CSF | - |
dc.subject.keywordPlus | GASTROINTESTINAL-TRACT | - |
dc.subject.keywordPlus | AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | IMMUNE HOMEOSTASIS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MICE | - |
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