DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Mi-Jeong | ko |
dc.contributor.author | Sheng, Ren | ko |
dc.contributor.author | Silkov, Antonina | ko |
dc.contributor.author | Jung, Da-Jung | ko |
dc.contributor.author | Wang, Zhi-Gang | ko |
dc.contributor.author | Xin, Yao | ko |
dc.contributor.author | Kim, Hyunjin | ko |
dc.contributor.author | Thiagarajan-Rosenkranz, Pallavi | ko |
dc.contributor.author | Song, Seohyeon | ko |
dc.contributor.author | Yoon, Youngdae | ko |
dc.contributor.author | Nam, Wonhee | ko |
dc.contributor.author | Kim, Ilshin | ko |
dc.contributor.author | Kim, Eui | ko |
dc.contributor.author | Lee, Dong-Gyu | ko |
dc.contributor.author | Chen, Yong | ko |
dc.contributor.author | Singaram, Indira | ko |
dc.contributor.author | Wang, Li | ko |
dc.contributor.author | Jang, Myoung Ho | ko |
dc.contributor.author | Hwang, Cheol-Sang | ko |
dc.contributor.author | Honig, Barry | ko |
dc.contributor.author | Ryu, Sungho | ko |
dc.contributor.author | Lorieau, Justin | ko |
dc.contributor.author | Kim, You-Me | ko |
dc.contributor.author | Cho, Wonhwa | ko |
dc.date.accessioned | 2018-03-21T02:53:06Z | - |
dc.date.available | 2018-03-21T02:53:06Z | - |
dc.date.created | 2018-03-14 | - |
dc.date.created | 2018-03-14 | - |
dc.date.created | 2018-03-14 | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | MOLECULAR CELL, v.62, no.1, pp.7 - 20 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240764 | - |
dc.description.abstract | The Src-homology 2 (SH2) domain is a protein interaction domain that directs myriad phosphotyrosine (pY)-signaling pathways. Genome-wide screening of human SH2 domains reveals that similar to 90% of SH2 domains bind plasma membrane lipids and many have high phosphoinositide specificity. They bind lipids using surface cationic patches separate from pY-binding pockets, thus binding lipids and the pY motif independently. The patches form grooves for specific lipid headgroup recognition or flat surfaces for non-specific membrane binding and both types of interaction are important for cellular function and regulation of SH2 domain-containing proteins. Cellular studies with ZAP70 showed that multiple lipids bind its C-terminal SH2 domain in a spatiotemporally specific manner and thereby exert exquisite spatiotemporal control over its protein binding and signaling activities in T cells. Collectively, this study reveals how lipids control SH2 domain-mediated cellular protein-protein interaction networks and suggest a new strategy for therapeutic modulation of pY-signaling pathways. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins | - |
dc.type | Article | - |
dc.identifier.wosid | 000374119600004 | - |
dc.identifier.scopusid | 2-s2.0-84962393747 | - |
dc.type.rims | ART | - |
dc.citation.volume | 62 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 7 | - |
dc.citation.endingpage | 20 | - |
dc.citation.publicationname | MOLECULAR CELL | - |
dc.identifier.doi | 10.1016/j.molcel.2016.01.027 | - |
dc.contributor.localauthor | Kim, You-Me | - |
dc.contributor.nonIdAuthor | Park, Mi-Jeong | - |
dc.contributor.nonIdAuthor | Sheng, Ren | - |
dc.contributor.nonIdAuthor | Silkov, Antonina | - |
dc.contributor.nonIdAuthor | Jung, Da-Jung | - |
dc.contributor.nonIdAuthor | Wang, Zhi-Gang | - |
dc.contributor.nonIdAuthor | Xin, Yao | - |
dc.contributor.nonIdAuthor | Kim, Hyunjin | - |
dc.contributor.nonIdAuthor | Thiagarajan-Rosenkranz, Pallavi | - |
dc.contributor.nonIdAuthor | Song, Seohyeon | - |
dc.contributor.nonIdAuthor | Yoon, Youngdae | - |
dc.contributor.nonIdAuthor | Nam, Wonhee | - |
dc.contributor.nonIdAuthor | Kim, Ilshin | - |
dc.contributor.nonIdAuthor | Kim, Eui | - |
dc.contributor.nonIdAuthor | Lee, Dong-Gyu | - |
dc.contributor.nonIdAuthor | Chen, Yong | - |
dc.contributor.nonIdAuthor | Singaram, Indira | - |
dc.contributor.nonIdAuthor | Wang, Li | - |
dc.contributor.nonIdAuthor | Jang, Myoung Ho | - |
dc.contributor.nonIdAuthor | Hwang, Cheol-Sang | - |
dc.contributor.nonIdAuthor | Honig, Barry | - |
dc.contributor.nonIdAuthor | Ryu, Sungho | - |
dc.contributor.nonIdAuthor | Lorieau, Justin | - |
dc.contributor.nonIdAuthor | Cho, Wonhwa | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | SCAFFOLD PROTEINS | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | PHOSPHOINOSITIDE | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | SPECIFICITY | - |
dc.subject.keywordPlus | RESIDUES | - |
dc.subject.keywordPlus | DYNAMICS | - |
dc.subject.keywordPlus | ELECTROSTATICS | - |
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