Inositol pyrophosphates as multifaceted metabolites in the regulation of mammalian signaling networks

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Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases, which both phosphorylate inositol hexakisphosphate (IP6). In mammals, PP-IPs are implicated in diverse biological phenomena including cellular growth, vesicular trafficking, apoptosis, and metabolic homeostasis. Mechanistically, all the diverse actions of PP-IPs proceed in one of two ways: the PP-IPs modulate the activity of their target proteins either through allosteric binding or protein pyrophosphorylation. In this review, we highlight recent advances in our understanding of the pleiotropic functions of the mammalian PP-IPs and the metabolic enzymes that produce them. We also discuss some future challenges in the exploration of areas where PP-IPs play important but unknown roles in physiology and disease.
Publisher
TAYLOR & FRANCIS LTD
Issue Date
2018-01
Language
English
Article Type
Article
Keywords

DIPHOSPHOINOSITOL POLYPHOSPHATES; SACCHAROMYCES-CEREVISIAE; CONSERVED FAMILY; HEXAKISPHOSPHATE; PHOSPHATES; TURNOVER; PYROPHOSPHORYLATION; TETRAKISPHOSPHATE; PHOSPHORYLATION; PURIFICATION

Citation

ANIMAL CELLS AND SYSTEMS, v.22, no.1, pp.1 - 6

ISSN
1976-8354
DOI
10.1080/19768354.2017.1408684
URI
http://hdl.handle.net/10203/240393
Appears in Collection
BS-Journal Papers(저널논문)
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