Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells

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This work aimed at formulating paclitaxel (PTX) loaded cell penetrating peptide (CPP) coated Mn doped ZnS nanoparticles (Mn: ZnS NPs) for improved anti-cancer efficacy in vitro and in vivo. The developed PTX loaded Mn: ZnS NPs with different CPPs (PEN, pVEC and R9) showed enhanced anti-cancer effect compared to bare PTX, which has been validated by MTT assay followed by apoptosis assay and DNA fragmentation analysis. The in vivo bio-distribution and anti-cancer efficacy was studied on breast cancer xenograft model showing maximum tumor localization and enhanced therapeutic efficacy with R9 coated Mn: ZnS NPs (R9: Mn: ZnS NPs) and was confirmed by H/E staining. Thus, R9: Mn: ZnS NPs could be an ideal theranostic nano-carrier for PTX with enhanced the rapeutic efficacy toward cancer cells, where penetration and sustainability of therapeutics are essential.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2018-01
Language
English
Article Type
Article
Keywords

ZNS QUANTUM DOTS; BREAST-CANCER; SURFACE PASSIVATION; GOLD NANOPARTICLES; DRUG-DELIVERY; FLUORESCENCE; THERAPY; PH

Citation

SCIENTIFIC REPORTS, v.8

ISSN
2045-2322
DOI
10.1038/s41598-018-20255-x
URI
http://hdl.handle.net/10203/240389
Appears in Collection
BiS-Journal Papers(저널논문)CBE-Journal Papers(저널논문)
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