DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jihye | ko |
dc.contributor.author | Chang, Dong-Yeop | ko |
dc.contributor.author | Lee, Hyun Woong | ko |
dc.contributor.author | Lee, Hoyoung | ko |
dc.contributor.author | Kim, Jong Hoon | ko |
dc.contributor.author | Sung, Pil Soo | ko |
dc.contributor.author | Kim, Kyung Hwan | ko |
dc.contributor.author | Hong, Seon-Hui | ko |
dc.contributor.author | Kang, Wonseok | ko |
dc.contributor.author | Lee, Jino | ko |
dc.contributor.author | Shin, So Youn | ko |
dc.contributor.author | Yu, Hee Tae | ko |
dc.contributor.author | You, Soo-Seong | ko |
dc.contributor.author | Choi, Yoon Seok | ko |
dc.contributor.author | Oh, In-Soo | ko |
dc.contributor.author | Lee, Dong Ho | ko |
dc.contributor.author | Lee, Dong Hyeon | ko |
dc.contributor.author | Jung, Min Kyung | ko |
dc.contributor.author | Suh, Kyung-Suk | ko |
dc.contributor.author | Hwang, Shin | ko |
dc.contributor.author | Kim, Won | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Kim, Hyung Joon | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2018-02-21T05:34:29Z | - |
dc.date.available | 2018-02-21T05:34:29Z | - |
dc.date.created | 2018-01-29 | - |
dc.date.created | 2018-01-29 | - |
dc.date.created | 2018-01-29 | - |
dc.date.created | 2018-01-29 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | IMMUNITY, v.48, no.1, pp.161 - + | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | http://hdl.handle.net/10203/240096 | - |
dc.description.abstract | Acute hepatitis A (AHA) involves severe CD8(+) T cell-mediated liver injury. Here we showed during AHA, CD8(+) T cells specific to unrelated viruses became activated. Hepatitis A virus (HAV)-infected cells produced IL-15 that induced T cell receptor (TCR)-independent activation of memory CD8(+) T cells. TCR-independent activation of non-HAV-specific CD8(+) T cells were detected in patients, as indicated by NKG2D upregulation, a marker of TCR-independent T cell activation by IL-15. CD8(+) T cells derived from AHA patients exerted innate-like cytotoxicity triggered by activating receptors NKG2D and NKp30 without TCR engagement. We demonstrated that the severity of liver injury in AHA patients correlated with the activation of HAV-unrelated virus-specific CD8(+) T cells and the innate-like cytolytic activity of CD8(+) T cells, but not the activation of HAV-specific T cells. Thus, host injury in AHA is associated with innate-like cytotoxicity of bystander-activated CD8(+) T cells, a result with implications for acute viral diseases. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Innate-like Cytotoxic Function of Bystander-Activated CD8(+) T Cells Is Associated with Liver Injury in Acute Hepatitis A | - |
dc.type | Article | - |
dc.identifier.wosid | 000422751600018 | - |
dc.identifier.scopusid | 2-s2.0-85061173739 | - |
dc.type.rims | ART | - |
dc.citation.volume | 48 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 161 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | IMMUNITY | - |
dc.identifier.doi | 10.1016/j.immuni.2017.11.025 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Lee, Hyun Woong | - |
dc.contributor.nonIdAuthor | Lee, Dong Ho | - |
dc.contributor.nonIdAuthor | Lee, Dong Hyeon | - |
dc.contributor.nonIdAuthor | Suh, Kyung-Suk | - |
dc.contributor.nonIdAuthor | Hwang, Shin | - |
dc.contributor.nonIdAuthor | Kim, Won | - |
dc.contributor.nonIdAuthor | Kim, Hyung Joon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TRANSGENIC MOUSE MODEL | - |
dc.subject.keywordPlus | C-VIRUS-INFECTION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | VIRAL-INFECTION | - |
dc.subject.keywordPlus | B-VIRUS | - |
dc.subject.keywordPlus | HETEROLOGOUS IMMUNITY | - |
dc.subject.keywordPlus | FULMINANT-HEPATITIS | - |
dc.subject.keywordPlus | IL-15 | - |
dc.subject.keywordPlus | IMMUNOPATHOLOGY | - |
dc.subject.keywordPlus | DISEASE | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.