IL-17A-Producing Foxp3(+) Regulatory T Cells and Human Diseases

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CD4(+)Foxp3(+) regulatory T (Treg) cells play major roles in immune homeostasis. While CD4(+)Foxp3(+) Treg cells act to suppress other immune effector cells, there is growing evidence that they also produce pro-inflammatory cytokines, such as IL-17A, in inflammatory conditions. The pro-inflammatory cytokine milieu, toll-like receptor (TLR) signaling, and specific transcription factors are important for the production of IL-17A by CD4(+)Foxp3(+) Treg cells. In particular, IL-17A-producing CD4(+)Foxp3(+) Treg cells express ROR gamma t, the T helper (Th) 17-specific transcription factor, in addition to Foxp3. IL-17A-producing CD4(+)Foxp3(+) Treg cells are also involved in the pathogenesis of various diseases. Here we review the mechanisms underlying the induction of IL-17A-producing CD4(+)Foxp3(+) Treg cells and the roles of these cells in human disease.
Publisher
KOREA ASSOC IMMUNOLOGISTS
Issue Date
2017-10
Language
English
Article Type
Review
Keywords

TOLL-LIKE-RECEPTORS; INFLAMMATORY-BOWEL-DISEASE; TRANSCRIPTION FACTOR FOXP3; TH17 CELLS; TGF-BETA; SUPPRESSIVE FUNCTION; CANDIDA-ALBICANS; STAT3-DEPENDENT MANNER; IL-17-PRODUCING CELLS; AUTOIMMUNE-DISEASES

Citation

IMMUNE NETWORK, v.17, no.5, pp.276 - 286

ISSN
1598-2629
DOI
10.4110/in.2017.17.5.276
URI
http://hdl.handle.net/10203/238841
Appears in Collection
MSE-Journal Papers(저널논문)
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