Functional Polysaccharide Sutures Prepared by Wet Fusion of Interfacial Polyelectrolyte Complexation Fibers

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This study reports polysaccharide-based fibers that can be utilized as biocompatible functional sutures. Fibers are spontaneously formed by spinning at the interface between two oppositely charged polysaccharide solutions. Unlike the common belief that polysaccharide fibers prepared by electrostatic interactions would exhibit weak mechanical strength, it is demonstrated that fibers spun at the interface between two droplets of positively charged chitosan and negatively charged heparin can exhibit high mechanical strength through spontaneous wet-state fusion of interfiber strands at a spinning wheel. Dry solidification results in multistranded fibers that were approximate to 100 mu m in diameter with a tensile strength of approximate to 220 MPa. Post fibrous manipulation yields various morphology with straight or twisted fibers, fabrics, or springs. To demonstrate application of the fiber, it is applied as a medical suture. As heparin has a unique ability to bind adeno-associated virus (AAV), a therapeutic, biocompatible suture exhibiting localized AAV-mediated gene delivery function can be prepared. This study shows that multistrand fusion of fibers, formed by weak, electrostatic interactions and followed by drying solidification counterintuitively results in mechanically strong, functional fibers with various potential applications.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2017-11
Language
English
Article Type
Article
Keywords

GENE DELIVERY; CONTROLLED-RELEASE; CHITOSAN; HEPARIN; THERAPY; DEACETYLATION; NANOPARTICLES; COMPOSITE; MOLECULES; HYDROGELS

Citation

ADVANCED FUNCTIONAL MATERIALS, v.27, no.42

ISSN
1616-301X
DOI
10.1002/adfm.201702017
URI
http://hdl.handle.net/10203/228613
Appears in Collection
CH-Journal Papers(저널논문)
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