Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila

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dc.contributor.authorLee, Sung Baeko
dc.contributor.authorKim, Wonhoko
dc.contributor.authorLee, Sungkyuko
dc.contributor.authorChung, Jongkyeongko
dc.date.accessioned2007-12-03T02:07:12Z-
dc.date.available2007-12-03T02:07:12Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2007-06-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.358, no.2, pp.534 - 539-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/2258-
dc.description.abstractMutations in LRRK2/PARK8 are linked to autosomal dominant forms of Parkinson's disease, but the pathogenic mechanism of LRRK2-associated Parkinson's disease is not fully understood. Moreover, in vivo functions of LRRK2 have not been addressed so far. Thus, we generated and characterized transgenic animals and loss-of-function mutants for LRRK, a sole Drosophila orthologue of human LRRK2. While transgenic expression of pathogenic mutant and wild type LRRK did not show any significant defects, LRRK loss-of-function mutants exhibited severely impaired locomotive activity. Moreover, dopaminergic neurons in LRRK mutants showed a severe reduction in tyrosine hydroxylase immunostaining and shrunken morphology, implicating their degeneration in the mutants. Collectively, our findings unprecedentedly show in vivo that LRRK2 is critical for the integrity of dopaminergic neurons and intact locomotive activity in Drosophila. (C) 2007 Elsevier Inc. All rights reserved.-
dc.description.sponsorshipThe work was supported by a National Creative Research Initiatives Grant (R16-2001-002-01001-0) from the Korean Ministry of Science and Technology/KOSEF.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectPARKINSONS-DISEASE-
dc.subjectLRRK2 G2019S-
dc.subjectMUTATIONS-
dc.subjectLOCALIZATION-
dc.subjectPATHOLOGY-
dc.subjectMUTANTS-
dc.subjectBRAIN-
dc.titleLoss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila-
dc.typeArticle-
dc.identifier.wosid000246927300025-
dc.identifier.scopusid2-s2.0-34248574535-
dc.type.rimsART-
dc.citation.volume358-
dc.citation.issue2-
dc.citation.beginningpage534-
dc.citation.endingpage539-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1016/j.bbrc.2007.04.156-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorChung, Jongkyeong-
dc.contributor.nonIdAuthorLee, Sung Bae-
dc.contributor.nonIdAuthorKim, Wonho-
dc.contributor.nonIdAuthorLee, Sungkyu-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorParkinson&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthortyrosine hydroxylase-
dc.subject.keywordPlusPARKINSONS-DISEASE-
dc.subject.keywordPlusLRRK2 G2019S-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusLOCALIZATION-
dc.subject.keywordPlusPATHOLOGY-
dc.subject.keywordPlusMUTANTS-
dc.subject.keywordPlusBRAIN-
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