Neural Signals Related to Outcome Evaluation Are Stronger in CA1 than CA3

Cited 5 time in webofscience Cited 0 time in scopus
  • Hit : 190
  • Download : 63
DC FieldValueLanguage
dc.contributor.authorLee, Sung-Hyunko
dc.contributor.authorHuh, Namjungko
dc.contributor.authorLee, Jong Wonko
dc.contributor.authorGhim, Jeong-Wookko
dc.contributor.authorLee, Inahko
dc.contributor.authorJung, Min Whanko
dc.date.accessioned2017-07-18T06:31:48Z-
dc.date.available2017-07-18T06:31:48Z-
dc.date.created2017-07-10-
dc.date.created2017-07-10-
dc.date.issued2017-06-
dc.identifier.citationFRONTIERS IN NEURAL CIRCUITS, v.11-
dc.identifier.issn1662-5110-
dc.identifier.urihttp://hdl.handle.net/10203/224883-
dc.description.abstractWe have shown previously that CA1 conveys significant neural signals necessary to update value of the chosen target, namely chosen value and reward signals. To better understand hippocampal neural processes related to valuation, we compared chosen value-and reward-related neural activity between the CA3 and CA1 regions. Single units were recorded with tetrodes from the dorsal CA3 and CA1 regions of rats performing a dynamic foraging task, and chosen value-and reward-related neural activity was estimated using a reinforcement learning model and multiple regression analyses. Neural signals for chosen value and reward converged in both CA3 and CA1 when a trial outcome was revealed. However, these neural signals were stronger in CA1 than CA3. Consequently, neural signals for reward prediction error and updated chosen value were stronger in CA1 than CA3. Together with our previous finding that CA1 conveys stronger value signals than the subiculum, our results raise the possibility that CA1 might play a particularly important role among hippocampal subregions in evaluating experienced events.-
dc.languageEnglish-
dc.publisherFRONTIERS MEDIA SA-
dc.subjectMEDIAL PREFRONTAL CORTEX-
dc.subjectNUCLEUS-REUNIENS-THALAMI-
dc.subjectLONG-TERM POTENTIATION-
dc.subjectPLACE-CELL SEQUENCES-
dc.subjectSEQUENTIAL EXPERIENCE-
dc.subjectHIPPOCAMPAL SYNAPSES-
dc.subjectNEURONS ENCODE-
dc.subjectAWAKE STATE-
dc.subjectMEMORY-
dc.subjectRAT-
dc.titleNeural Signals Related to Outcome Evaluation Are Stronger in CA1 than CA3-
dc.typeArticle-
dc.identifier.wosid000403771900001-
dc.identifier.scopusid2-s2.0-85021388157-
dc.type.rimsART-
dc.citation.volume11-
dc.citation.publicationnameFRONTIERS IN NEURAL CIRCUITS-
dc.identifier.doi10.3389/fncir.2017.00040-
dc.contributor.localauthorJung, Min Whan-
dc.contributor.nonIdAuthorLee, Sung-Hyun-
dc.contributor.nonIdAuthorHuh, Namjung-
dc.contributor.nonIdAuthorLee, Jong Won-
dc.contributor.nonIdAuthorGhim, Jeong-Wook-
dc.contributor.nonIdAuthorLee, Inah-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorhippocampus-
dc.subject.keywordAuthorreinforcement learning-
dc.subject.keywordAuthorchosen value-
dc.subject.keywordAuthordynamic foraging task-
dc.subject.keywordAuthordecision making-
dc.subject.keywordAuthorT-maze-
dc.subject.keywordAuthorrat-
dc.subject.keywordPlusMEDIAL PREFRONTAL CORTEX-
dc.subject.keywordPlusNUCLEUS-REUNIENS-THALAMI-
dc.subject.keywordPlusLONG-TERM POTENTIATION-
dc.subject.keywordPlusPLACE-CELL SEQUENCES-
dc.subject.keywordPlusSEQUENTIAL EXPERIENCE-
dc.subject.keywordPlusHIPPOCAMPAL SYNAPSES-
dc.subject.keywordPlusNEURONS ENCODE-
dc.subject.keywordPlusAWAKE STATE-
dc.subject.keywordPlusMEMORY-
dc.subject.keywordPlusRAT-
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 5 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0