Measurements of Morphological and Biophysical Alterations in Individual Neuron Cells Associated with Early Neurotoxic Effects in Parkinson's Disease

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dc.contributor.authorYang, Su-Ako
dc.contributor.authorYoon, Jongheeko
dc.contributor.authorKim, Kyoohyunko
dc.contributor.authorPark, YongKeunko
dc.date.accessioned2017-06-16T03:58:43Z-
dc.date.available2017-06-16T03:58:43Z-
dc.date.created2017-06-12-
dc.date.created2017-06-12-
dc.date.created2017-06-12-
dc.date.created2017-06-12-
dc.date.issued2017-05-
dc.identifier.citationCYTOMETRY PART A, v.91, no.5, pp.510 - 518-
dc.identifier.issn1552-4922-
dc.identifier.urihttp://hdl.handle.net/10203/224067-
dc.description.abstractParkinson's disease (PD) is a common neurodegenerative disease. However, therapeutic methods of PD are still limited due to complex pathophysiology in PD. Here, optical measurements of individual neurons from in vitro PD model using optical diffraction tomography (ODT) are presented. By measuring 3D refractive index distribution of neurons, morphological and biophysical alterations in in-vitro PD model are quantitatively investigated. It was found that neurons show apoptotic features in early PD progression. The present approach will open up new opportunities for quantitative investigation of the pathophysiology of various neurodegenerative diseases. (C) 2017 International Society for Advancement of Cytometry-
dc.languageEnglish-
dc.publisherWILEY-BLACKWELL-
dc.titleMeasurements of Morphological and Biophysical Alterations in Individual Neuron Cells Associated with Early Neurotoxic Effects in Parkinson's Disease-
dc.typeArticle-
dc.identifier.wosid000401842700012-
dc.identifier.scopusid2-s2.0-85018641960-
dc.type.rimsART-
dc.citation.volume91-
dc.citation.issue5-
dc.citation.beginningpage510-
dc.citation.endingpage518-
dc.citation.publicationnameCYTOMETRY PART A-
dc.identifier.doi10.1002/cyto.a.23110-
dc.contributor.localauthorPark, YongKeun-
dc.contributor.nonIdAuthorYang, Su-A-
dc.contributor.nonIdAuthorYoon, Jonghee-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorParkinson&apos-
dc.subject.keywordAuthors disease-
dc.subject.keywordAuthorquantitative phase imaging-
dc.subject.keywordAuthor3D refractive index tomography-
dc.subject.keywordAuthorcell death-
dc.subject.keywordAuthorlabel-free-
dc.subject.keywordPlusOPTICAL DIFFRACTION TOMOGRAPHY-
dc.subject.keywordPlusSH-SY5Y NEUROBLASTOMA-CELLS-
dc.subject.keywordPlusLABEL-FREE CHARACTERIZATION-
dc.subject.keywordPlusTRANSFORM LIGHT-SCATTERING-
dc.subject.keywordPlusQUANTITATIVE PHASE-
dc.subject.keywordPlusDOPAMINERGIC-NEURONS-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusINDUCED APOPTOSIS-
dc.subject.keywordPlusBLOOD-CELLS-
dc.subject.keywordPlusLIVE CELLS-
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