Measurements of Morphological and Biophysical Alterations in Individual Neuron Cells Associated with Early Neurotoxic Effects in Parkinson's Disease

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Parkinson's disease (PD) is a common neurodegenerative disease. However, therapeutic methods of PD are still limited due to complex pathophysiology in PD. Here, optical measurements of individual neurons from in vitro PD model using optical diffraction tomography (ODT) are presented. By measuring 3D refractive index distribution of neurons, morphological and biophysical alterations in in-vitro PD model are quantitatively investigated. It was found that neurons show apoptotic features in early PD progression. The present approach will open up new opportunities for quantitative investigation of the pathophysiology of various neurodegenerative diseases. (C) 2017 International Society for Advancement of Cytometry
Publisher
WILEY-BLACKWELL
Issue Date
2017-05
Language
English
Article Type
Article
Citation

CYTOMETRY PART A, v.91, no.5, pp.510 - 518

ISSN
1552-4922
DOI
10.1002/cyto.a.23110
URI
http://hdl.handle.net/10203/224067
Appears in Collection
PH-Journal Papers(저널논문)
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