Systems approach to characterize the metabolism of liver cancer stem cells expressing CD133

Cited 8 time in webofscience Cited 0 time in scopus
  • Hit : 231
  • Download : 51
Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and compared the global metabolic phenotype between LCSCs and non-LCSCs using transcriptome and metabolome data. We also reconstructed genome-scale metabolic models (GEMs) for LCSC and non-LCSC to comparatively examine differences in their metabolism at genome-scale. We demonstrated that LCSCs exhibited an increased proliferation rate through enhancing glycolysis compared with non-LCSCs. We also confirmed that MYC, a central point of regulation in cancer metabolism, was significantly up-regulated in LCSCs compared with non-LCSCs. Moreover, LCSCs tend to have less active fatty acid oxidation. In this study, the metabolic characteristics of LCSCs were identified using integrative systems analysis, and these characteristics could be potential cures for the resistance of liver cancer cells to anticancer treatments.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2017-04
Language
English
Article Type
Article
Keywords

HEPATOCELLULAR-CARCINOMA; GLUTAMINE-METABOLISM; GROWTH; ACTIVATION; DIAGNOSIS; 1-METHYLNICOTINAMIDE; RECONSTRUCTION; PROLIFERATION; ANGIOGENESIS; MIGRATION

Citation

SCIENTIFIC REPORTS, v.7

ISSN
2045-2322
DOI
10.1038/srep45557
URI
http://hdl.handle.net/10203/223689
Appears in Collection
CBE-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 8 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0