Separation or binding? Role of the dentate gyrus in hippocampal mnemonic processing

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As a major component of the hippocampal trisynaptic circuit, the dentate gyrus (DG) relays inputs from the entorhinal cortex to the CA3 subregion. Although the anatomy of the DG is well characterized, its contribution to hippocampal mnemonic processing is still unclear. A currently popular theory proposes that the primary function of the DG is to orthogonalize incoming input patterns into non-overlapping patterns (pattern separation). We critically review the available data and conclude that the theoretical support and empirical evidence for this theory are not strong. We then review an alternative theory that posits a role for the DG in binding together different types of incoming sensory information. We conclude that 'binding' better captures the contribution of the DG to memory encoding than 'pattern separation'. (C) 2017 Elsevier Ltd. All rights reserved.
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Issue Date
2017-04
Language
English
Article Type
Review
Keywords

PROGRAMMED CELL-DEATH; LONG-TERM POTENTIATION; SPATIAL-PATTERN SEPARATION; OCCURRING NEURONAL DEATH; ADULT-GENERATED NEURONS; KNOCK-OUT MICE; ENTORHINAL CORTEX; GRANULE CELLS; PERIRHINAL CORTEX; MOSSY FIBER

Citation

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, v.75, pp.183 - 194

ISSN
0149-7634
DOI
10.1016/j.neubiorev.2017.01.049
URI
http://hdl.handle.net/10203/223684
Appears in Collection
BS-Journal Papers(저널논문)
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