Synthesis and applications of DNA-mediated nanostructures

Abstract

Nanomaterials have been reported as promising materials in particular applications, such as sensors, drug delivery systems and optical devices. Over the recent decades, due to the molecular precision and program-mability, DNA has been used to generate nanostructures as biocompatible templates and spatial tools for the assembly of nanoscale building blocks. In this work, we report the Au nanoparticle-Carbon quantum dot con-jugates by DNA double helix with enhanced fluorescence properties, with easily synthesized carbon dot. The nanoassembly will be applicable to sensors with improved surface-enhanced raman scattering sensitivity. Also, we synthesized rigid three-dimensional tetrahedral DNA nanostructure with six different single strands by self-assembly, including aptamers and fluorophores attached at the edges for effective recognition abili-ties and delivery systems. Furthermore, We investigated single strand DNA(ssDNA) governed- morphology change of AgNP in seedless synthesis. More specifically we explored the effect of ssDNA as capping agent during AgNP synthesis-polyhomonucloetides such as polyA, polyT, polyD, & polyC. The presence of 20-mer oligo-A directed AgNPs growth into triangular nanoplates with different truncation extents, and oligo-T di-rected the sphere nanoparticles. Oligo-C and ？G appeared as rough nanoparticles.