IPMK and beta-catenin mediate PLC-beta 1-dependent signaling in myogenic differentiation

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dc.contributor.authorRamazzotti, Giuliako
dc.contributor.authorBilli, Anna Mariako
dc.contributor.authorManzoli, Luciako
dc.contributor.authorMazzetti, Cristinako
dc.contributor.authorRuggeri, Alessandrako
dc.contributor.authorErneux, Christopheko
dc.contributor.authorKim, Seyunko
dc.contributor.authorSuh, Pann-Ghillko
dc.contributor.authorCocco, Lucioko
dc.contributor.authorFaenza, Ireneko
dc.date.accessioned2017-03-28T05:36:15Z-
dc.date.available2017-03-28T05:36:15Z-
dc.date.created2017-02-02-
dc.date.created2017-02-02-
dc.date.issued2016-12-
dc.identifier.citationONCOTARGET, v.7, no.51, pp.84118 - 84127-
dc.identifier.issn1949-2553-
dc.identifier.urihttp://hdl.handle.net/10203/220747-
dc.description.abstractIn previous studies, we have reported that phospholipase C (PLC)-beta 1 plays a crucial role in myogenic differentiation and we determined the importance of its catalytic activity for the initiation of this process. Here we define the effectors that take part to its signaling pathway. We show that the Inositol Polyphosphate Multikinase (IPMK) is able to promote myogenic differentiation since its overexpression determines the up-regulation of several myogenic markers. Moreover, we demonstrate that IPMK activates the same cyclin D3 promoter region targeted by PLC-beta 1 and that IPMK-induced promoter activation relies upon c-jun binding to the promoter, as we have shown previously for PLC-beta 1. Furthermore, our data shows that IPMK overexpression causes an increase in beta-catenin translocation and accumulation to the nuclei of differentiating myoblasts resulting in higher MyoD activation. Finally, we describe that PLC-beta 1 overexpression determines too an increase in beta-catenin translocation and that PLC-beta 1, IPMK and beta-catenin are mediators of the same signaling pathway since their overexpression results in cyclin D3 and myosin heavy chain (MYH) induction.-
dc.languageEnglish-
dc.publisherIMPACT JOURNALS LLC-
dc.subjectINOSITOL POLYPHOSPHATE MULTIKINASE-
dc.subjectSKELETAL-MUSCLE DIFFERENTIATION-
dc.subjectGENE-EXPRESSION-
dc.subjectNUCLEAR PLC-BETA(1)-
dc.subjectPHOSPHOLIPASE-C-
dc.subjectWNT PATHWAY-
dc.subjectCOACTIVATOR-
dc.subjectPROMOTER-
dc.subjectPENTAKISPHOSPHATE-
dc.subjectINDUCTION-
dc.titleIPMK and beta-catenin mediate PLC-beta 1-dependent signaling in myogenic differentiation-
dc.typeArticle-
dc.identifier.wosid000391353200026-
dc.identifier.scopusid2-s2.0-85007429438-
dc.type.rimsART-
dc.citation.volume7-
dc.citation.issue51-
dc.citation.beginningpage84118-
dc.citation.endingpage84127-
dc.citation.publicationnameONCOTARGET-
dc.identifier.doi10.18632/oncotarget.11527-
dc.contributor.localauthorKim, Seyun-
dc.contributor.nonIdAuthorRamazzotti, Giulia-
dc.contributor.nonIdAuthorBilli, Anna Maria-
dc.contributor.nonIdAuthorManzoli, Lucia-
dc.contributor.nonIdAuthorMazzetti, Cristina-
dc.contributor.nonIdAuthorRuggeri, Alessandra-
dc.contributor.nonIdAuthorErneux, Christophe-
dc.contributor.nonIdAuthorSuh, Pann-Ghill-
dc.contributor.nonIdAuthorCocco, Lucio-
dc.contributor.nonIdAuthorFaenza, Irene-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthormyogenic differentiation-
dc.subject.keywordAuthorphospholipase C-beta 1-
dc.subject.keywordAuthorIPMK-
dc.subject.keywordAuthorbeta-catenin-
dc.subject.keywordAuthorinositol phosphates-
dc.subject.keywordPlusINOSITOL POLYPHOSPHATE MULTIKINASE-
dc.subject.keywordPlusSKELETAL-MUSCLE DIFFERENTIATION-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusNUCLEAR PLC-BETA(1)-
dc.subject.keywordPlusPHOSPHOLIPASE-C-
dc.subject.keywordPlusWNT PATHWAY-
dc.subject.keywordPlusCOACTIVATOR-
dc.subject.keywordPlusPROMOTER-
dc.subject.keywordPlusPENTAKISPHOSPHATE-
dc.subject.keywordPlusINDUCTION-
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