IPMK and beta-catenin mediate PLC-beta 1-dependent signaling in myogenic differentiation

Cited 2 time in webofscience Cited 0 time in scopus
  • Hit : 243
  • Download : 0
In previous studies, we have reported that phospholipase C (PLC)-beta 1 plays a crucial role in myogenic differentiation and we determined the importance of its catalytic activity for the initiation of this process. Here we define the effectors that take part to its signaling pathway. We show that the Inositol Polyphosphate Multikinase (IPMK) is able to promote myogenic differentiation since its overexpression determines the up-regulation of several myogenic markers. Moreover, we demonstrate that IPMK activates the same cyclin D3 promoter region targeted by PLC-beta 1 and that IPMK-induced promoter activation relies upon c-jun binding to the promoter, as we have shown previously for PLC-beta 1. Furthermore, our data shows that IPMK overexpression causes an increase in beta-catenin translocation and accumulation to the nuclei of differentiating myoblasts resulting in higher MyoD activation. Finally, we describe that PLC-beta 1 overexpression determines too an increase in beta-catenin translocation and that PLC-beta 1, IPMK and beta-catenin are mediators of the same signaling pathway since their overexpression results in cyclin D3 and myosin heavy chain (MYH) induction.
Publisher
IMPACT JOURNALS LLC
Issue Date
2016-12
Language
English
Article Type
Article
Keywords

INOSITOL POLYPHOSPHATE MULTIKINASE; SKELETAL-MUSCLE DIFFERENTIATION; GENE-EXPRESSION; NUCLEAR PLC-BETA(1); PHOSPHOLIPASE-C; WNT PATHWAY; COACTIVATOR; PROMOTER; PENTAKISPHOSPHATE; INDUCTION

Citation

ONCOTARGET, v.7, no.51, pp.84118 - 84127

ISSN
1949-2553
DOI
10.18632/oncotarget.11527
URI
http://hdl.handle.net/10203/220747
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 2 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0