EEG dynamics in patients with Alzheimers disease

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Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by cognitive and intellectual deficits and behavior disturbance. The electroencephalogram (EEG) has been used as a tool for diagnosing AD for several decades. The hallmark of EEG abnormalities in AD patients is a shift of the power spectrum to lower frequencies and a decrease in coherence of fast rhythms. These abnormalities are thought to be associated with functional disconnections among cortical areas resulting from death of cortical neurons, axonal pathology, cholinergic deficits, etc. This article reviews main findings of EEG abnormalities in AD patients obtained from conventional spectral analysis and nonlinear dynamical methods. In particular, nonlinear alterations in the EEG of AD patients, i.e. a decreased complexity of EEG patterns and reduced information transmission among cortical areas, and their clinical implications are discussed. For future studies, improvement of the accuracy of differential diagnosis and early detection of AD based on multimodal approaches, longitudinal studies on nonlinear dynamics of the EEG, drug effects on the EEG dynamics, and linear and nonlinear functional connectivity among cortical regions in AD are proposed to be investigated. EEG abnormalities of AD patients are characterized by slowed mean frequency, less complex activity, and reduced coherences among cortical regions. These abnormalities suggest that the EEG has utility as a valuable tool for differential and early diagnosis of AD. (C) 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Publisher
ELSEVIER IRELAND LTD
Issue Date
2004-07
Language
English
Article Type
Review
Keywords

MILD COGNITIVE IMPAIRMENT; CEREBRAL-BLOOD-FLOW; BRAIN ELECTRICAL-ACTIVITY; QUANTITATIVE SPECTRAL ELECTROENCEPHALOGRAPHY; CHOLINE-ACETYLTRANSFERASE ACTIVITY; APOLIPOPROTEIN-E POLYMORPHISM; TERM TACRINE TREATMENT; TIME-SERIES METHODS; HUMAN ALPHA-RHYTHM; RESTING AWAKE EEG

Citation

CLINICAL NEUROPHYSIOLOGY, v.115, pp.1490 - 1505

ISSN
1388-2457
DOI
10.1016/j.clinph.2004.01.001
URI
http://hdl.handle.net/10203/21515
Appears in Collection
BiS-Journal Papers(저널논문)
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